A severe transfusion-dependent congenital dyserythropoietic anemia presenting as hydrops fetalis

A. Cantù-Rajnoldi, A. Zanella, U. Conter, P. Faccini, D. Soligo, G. Gornati, C. Vegni, U. Nicolini

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a case of congenital dyserythropoietic anaemia (CDA) presenting at week 20 of pregnancy hydrops fetalis and very severe anaemia. Fetal blood examination showed marked erythroblastosis with morphologic alterations while the basic haematological and biochemical tests were in the normal range. The fetus received intravascular red blood cells transfusion at 20 and 25 weeks of gestation. After a caesarean section at week 33 the child became transfusion dependent. Haematological investigations demonstrated that the child is affected by a CDA-like picture which, although morphologically similar to CDA II, is Ham test negative and does not show the typical membrane proteins alterations.

Original languageEnglish
Pages (from-to)530-533
Number of pages4
JournalBritish Journal of Haematology
Volume96
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Congenital dyserythropoietic anaemia
  • Fetal hydrops

ASJC Scopus subject areas

  • Hematology

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