TY - JOUR
T1 - A Sex-Based Analysis from the RAIN-CARDIOGROUP VII Study (VeRy Thin Stents for Patients with Left MAIn or BifurcatioN in Real Life) on Left Main Stenting
AU - Trabattoni, Daniela
AU - Gili, Sebastiano
AU - Teruzzi, Giovanni
AU - Omedè, Pierluigi
AU - Cerrato, Enrico
AU - Templin, Christian
AU - Capodanno, Davide
AU - Lüscher, Thomas
AU - Ryan, Nicola
AU - Venuti, Giuseppe
AU - Montabone, Andrea
AU - Wojakowski, Wojciech
AU - Rognoni, Andrea
AU - Helft, Gerard
AU - Gallo, Diego
AU - Biolè, Carlo Alberto
AU - Parma, Radoslaw
AU - Luca, Leonardo De
AU - Figini, Filippo
AU - Mitomo, Satoru
AU - Mattesini, Alessio
AU - Boccuzzi, Giacomo
AU - Quadri, Giorgio
AU - Wanha, Wojciech
AU - Smolka, Grzegorz
AU - Huczek, Zenon
AU - Chieffo, Alaide
AU - Nuñez-Gil, Ivan
AU - Morbiducci, Umberto
AU - Iannaccone, Mario
AU - Mario, Carlo Di
AU - Moretti, Claudio
AU - D'Amico, Maurizio
AU - Sheiban, Imad
AU - Escaned, Javier
AU - D'Ascenzo, Fabrizio
N1 - Publisher Copyright:
© 2020 HMP Communications. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Introduction. There is a lack of data on clinical outcomes of percutaneous coronary intervention (PCI) with ultrathin stents on unprotected left main (ULM) coronary artery comparing women and men. Methods. All patients treated with ULM-PCI with ultrathin stents (struts ≤81 μm) enrolled in the RAIN-CARDIOGROUP VII study were analyzed according to a sex-assessment evaluation. Major adverse cardiovascular event (MACE, a composite of all-cause death, myocardial infarction, target-lesion revascularization [TLR], and stent thrombosis) was the primary endpoint, whereas single components of MACE were the secondary endpoints. Results. Out of a cohort of 793 patients, a total of 172 women (21.7%) and 621 men (78.3%) were included. Compared with men, women were older and less frequently smokers, had more frequently a history of previous PCI, and presented more frequently with an acute coronary syndrome. Among women, ostial lesions were more prevalent and mean stent diameter was lower compared with men. After 13.4 months (range, 8.4-21.6 months), 32 women (18.6%) and 106 men (17.1%) experienced MACE (P=.64). Censoring follow-up data at 3 years, no differences were observed in MACE (16.9 vs 14.7 per 100•patient-years; log-rank P=.61) and their single components between women and men. At multivariate analysis, chronic kidney disease (hazard ratio [HR], 1.91: 95% confidence interval [CI], 1.23 to-2.95; P<.01) and acute coronary syndrome presentation (HR, 1.84; 95% CI, 1.22-2.77; P=.01) were independent predictors of MACE overall. Larger stent size (HR, 0.65; 95% CI, 0.48-0.89; P<.01) and longer dual-antiplatelet therapy duration (HR, 0.95; 95% CI, 0.90-0.99; P=.03) were associated with a reduced risk of MACE during the subsequent follow-up. Conclusion. Ultrathin stents offer low rates of MACE and TLR in the overall population without significant differences between sexes. J INVASIVE CARDIOL 2020;32(9):342-346. Epub 2020 June 22.
AB - Introduction. There is a lack of data on clinical outcomes of percutaneous coronary intervention (PCI) with ultrathin stents on unprotected left main (ULM) coronary artery comparing women and men. Methods. All patients treated with ULM-PCI with ultrathin stents (struts ≤81 μm) enrolled in the RAIN-CARDIOGROUP VII study were analyzed according to a sex-assessment evaluation. Major adverse cardiovascular event (MACE, a composite of all-cause death, myocardial infarction, target-lesion revascularization [TLR], and stent thrombosis) was the primary endpoint, whereas single components of MACE were the secondary endpoints. Results. Out of a cohort of 793 patients, a total of 172 women (21.7%) and 621 men (78.3%) were included. Compared with men, women were older and less frequently smokers, had more frequently a history of previous PCI, and presented more frequently with an acute coronary syndrome. Among women, ostial lesions were more prevalent and mean stent diameter was lower compared with men. After 13.4 months (range, 8.4-21.6 months), 32 women (18.6%) and 106 men (17.1%) experienced MACE (P=.64). Censoring follow-up data at 3 years, no differences were observed in MACE (16.9 vs 14.7 per 100•patient-years; log-rank P=.61) and their single components between women and men. At multivariate analysis, chronic kidney disease (hazard ratio [HR], 1.91: 95% confidence interval [CI], 1.23 to-2.95; P<.01) and acute coronary syndrome presentation (HR, 1.84; 95% CI, 1.22-2.77; P=.01) were independent predictors of MACE overall. Larger stent size (HR, 0.65; 95% CI, 0.48-0.89; P<.01) and longer dual-antiplatelet therapy duration (HR, 0.95; 95% CI, 0.90-0.99; P=.03) were associated with a reduced risk of MACE during the subsequent follow-up. Conclusion. Ultrathin stents offer low rates of MACE and TLR in the overall population without significant differences between sexes. J INVASIVE CARDIOL 2020;32(9):342-346. Epub 2020 June 22.
KW - Coronary artery disease
KW - Drug-eluting stents
KW - Gender medicine
KW - Left main
KW - Percutaneous coronary interventions
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M3 - Article
C2 - 32568097
AN - SCOPUS:85090174426
VL - 32
SP - 342
EP - 346
JO - Journal of Invasive Cardiology
JF - Journal of Invasive Cardiology
SN - 1042-3931
IS - 9
ER -