A short incubation with PGE2 affects the proliferative response of t lymphocytes to PWM

Gerardo Santarpia, Andrea Valenti, Letterio Loteta, Vincenza Sofo, Antonino Sottile, Nicola Serrao, Francesca M. Salmeri, Diana Teti

Research output: Contribution to journalArticle

Abstract

In this study we have investigated the role of PGE2 in the activation of human T lymphocytes by PWM. A preincubation of these cells with molar concentrations of the prostaglandin ranging from 10-9 M to 10-4 M is able to reduce the expression of IL-2R and CD71 on T lymphocyte membrane during the first days of culture, while the DR molecule which is expressed later in the same experimental conditions is not affected by the treatment of T lymphocytes with PGE2. The PGE2-induced inhibition of IL-2R and CD71 well correlates with the reduction of 3H-thymidine incorporation by T cells, indicating that a preincubation of T lymphocytes with PGE2 profoundly affects the proliferative apparatus of these cells when they are stimulated by PWM.

Original languageEnglish
Pages (from-to)757-767
Number of pages11
JournalImmunopharmacology and Immunotoxicology
Volume14
Issue number4
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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