A short incubation with PGE2 affects the proliferative response of t lymphocytes to PWM

Gerardo Santarpia, Andrea Valenti, Letterio Loteta, Vincenza Sofo, Antonino Sottile, Nicola Serrao, Francesca M. Salmeri, Diana Teti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study we have investigated the role of PGE2 in the activation of human T lymphocytes by PWM. A preincubation of these cells with molar concentrations of the prostaglandin ranging from 10-9 M to 10-4 M is able to reduce the expression of IL-2R and CD71 on T lymphocyte membrane during the first days of culture, while the DR molecule which is expressed later in the same experimental conditions is not affected by the treatment of T lymphocytes with PGE2. The PGE2-induced inhibition of IL-2R and CD71 well correlates with the reduction of 3H-thymidine incorporation by T cells, indicating that a preincubation of T lymphocytes with PGE2 profoundly affects the proliferative apparatus of these cells when they are stimulated by PWM.

Original languageEnglish
Pages (from-to)757-767
Number of pages11
JournalImmunopharmacology and Immunotoxicology
Volume14
Issue number4
DOIs
Publication statusPublished - 1992

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T-cells
Lymphocytes
Dinoprostone
Pulse width modulation
T-Lymphocytes
Cell culture
Thymidine
Prostaglandins
Chemical activation
Membranes
Molecules

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

A short incubation with PGE2 affects the proliferative response of t lymphocytes to PWM. / Santarpia, Gerardo; Valenti, Andrea; Loteta, Letterio; Sofo, Vincenza; Sottile, Antonino; Serrao, Nicola; Salmeri, Francesca M.; Teti, Diana.

In: Immunopharmacology and Immunotoxicology, Vol. 14, No. 4, 1992, p. 757-767.

Research output: Contribution to journalArticle

Santarpia, G, Valenti, A, Loteta, L, Sofo, V, Sottile, A, Serrao, N, Salmeri, FM & Teti, D 1992, 'A short incubation with PGE2 affects the proliferative response of t lymphocytes to PWM', Immunopharmacology and Immunotoxicology, vol. 14, no. 4, pp. 757-767. https://doi.org/10.3109/08923979209009233
Santarpia, Gerardo ; Valenti, Andrea ; Loteta, Letterio ; Sofo, Vincenza ; Sottile, Antonino ; Serrao, Nicola ; Salmeri, Francesca M. ; Teti, Diana. / A short incubation with PGE2 affects the proliferative response of t lymphocytes to PWM. In: Immunopharmacology and Immunotoxicology. 1992 ; Vol. 14, No. 4. pp. 757-767.
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