TY - JOUR
T1 - A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents
AU - Carpenter, Chelsea
AU - Sidney, John
AU - Kolla, Ravi
AU - Nayak, Kaustuv
AU - Tomiyama, Helena
AU - Tomiyama, Claudia
AU - Padilla, Oscar A.
AU - Rozot, Virginie
AU - Ahamed, Syed F.
AU - Ponte, Carlos
AU - Rolla, Valeria
AU - Antas, Paulo R.
AU - Chandele, Anmol
AU - Kenneth, John
AU - Laxmi, Seetha
AU - Makgotlho, Edward
AU - Vanini, Valentina
AU - Ippolito, Giuseppe
AU - Kazanova, Alexandra S.
AU - Panteleev, Alexander V.
AU - Hanekom, Willem
AU - Mayanja-Kizza, Harriet
AU - Lewinsohn, David
AU - Saito, Mayuko
AU - McElrath, M. Juliana
AU - Boom, W. Henry
AU - Goletti, Delia
AU - Gilman, Robert
AU - Lyadova, Irina V.
AU - Scriba, Thomas J.
AU - Kallas, Esper G.
AU - Murali-Krishna, Kaja
AU - Sette, Alessandro
AU - Lindestam Arlehamn, Cecilia S.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.
AB - We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.
KW - BCG
KW - CD4
KW - LTBI
KW - T cell antigen
KW - Tuberculosis
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84948718070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948718070&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2015.07.001
DO - 10.1016/j.tube.2015.07.001
M3 - Article
AN - SCOPUS:84948718070
VL - 95
SP - 713
EP - 721
JO - Tuberculosis
JF - Tuberculosis
SN - 1472-9792
IS - 6
ER -