A similar 24-h blood pressure control is obtained by zofenopril and candesartan in primary hypertensive patients

G. Leonetti, A. Rappelli, S. Omboni, R. Ansuini, N. Acquarone, E. Antonucci, M. Campanini, E. Paracchini, L. Celegon, F. Lazzari, M. Crippa, D. Caruso, M. D'Avino, M. Di Biase, V. Manuppelli, P. L. Pellegrino, N. Etna, C. Fiorentini, S. Lucreziotti, F. GalettaF. Franzoni, R. Femia, R. Giovannetti, A. Auteri, F. Bruni, A. Leo, L. Lonati, G. C. Magnaghi, P. Sensale, O. Maiolica, C. Malinverni, S. Mangiameli, R. Cardillo, A. Antonelli, L. Mazzotta, R. Nami, D. P. Salvo, U. Pezzotti, G. Monti, P. Novati, R. Furlan, F. Perego, S. Pede, C. Pico, A. Renna, A. Margonato, R. Pizzetti, D. Prinzi, D. Smimmo, G. De Cicco, G. Napolitano, M. Reynaud, M. Piccoli, G. Cipollari, P. L. Saccà, U. Oliviero, E. L. Ettari, F. Scanferla, G. Rosato, F. Siano, G. M. Cianciucci, M. R. Pagliuca, A. Santucci, C. Ferri, G. B. Desideri, O. Zingaretti

Research output: Contribution to journalArticle

Abstract

Objective. To compare the antihypertensive effect of treatment with zofenopril vs candesartan by office and ambulatory blood pressure (BP). Design and methods. Following a 2-week wash-out from previous treatment, 236 grade I-II primary hypertensive patients were randomized double-blind to 12 weeks treatment with zofenopril 30 mg or candesartan 8 mg od. After 4 weeks, treatment was doubled in responder non-normalized (office systolic BP≥140 mmHg and office diastolic BP reduction ≥10 mmHg) or non-responder patients (office systolic BP≥140 mmHg and office diastolic BP reduction

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalBlood Pressure
Volume15
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Ambulatory blood pressure monitoring
  • Candesartan
  • Primary hypertension
  • Smoothness index
  • Trough-to-peak ratio
  • Zofenopril

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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    Leonetti, G., Rappelli, A., Omboni, S., Ansuini, R., Acquarone, N., Antonucci, E., Campanini, M., Paracchini, E., Celegon, L., Lazzari, F., Crippa, M., Caruso, D., D'Avino, M., Di Biase, M., Manuppelli, V., Pellegrino, P. L., Etna, N., Fiorentini, C., Lucreziotti, S., ... Zingaretti, O. (2006). A similar 24-h blood pressure control is obtained by zofenopril and candesartan in primary hypertensive patients. Blood Pressure, 15(SUPPL. 1), 18-26. https://doi.org/10.1080/08038020510046689