Abstract
BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3% higher in Graves' disease (p = 0.001) and 3% higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33% in Graves' disease; 17% in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20%; 42% in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.
| Original language | English |
|---|---|
| Pages (from-to) | 13-18 |
| Number of pages | 6 |
| Journal | Nuclear Medicine Review |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Autonomous thyroid nodule
- Graves' disease
- Guidelines
- MIRD
- Radioiodine
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment. / Skanjeti, Andrea; Miranti, Anna; Yabar, Gabriela Mariam Delgado; Bianciotto, Davide; Trevisiol, Edoardo; Stasi, Michele; Podio, Valerio.
In: Nuclear Medicine Review, Vol. 18, No. 1, 2015, p. 13-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment
AU - Skanjeti, Andrea
AU - Miranti, Anna
AU - Yabar, Gabriela Mariam Delgado
AU - Bianciotto, Davide
AU - Trevisiol, Edoardo
AU - Stasi, Michele
AU - Podio, Valerio
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3% higher in Graves' disease (p = 0.001) and 3% higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33% in Graves' disease; 17% in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20%; 42% in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.
AB - BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3% higher in Graves' disease (p = 0.001) and 3% higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33% in Graves' disease; 17% in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20%; 42% in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.
KW - Autonomous thyroid nodule
KW - Graves' disease
KW - Guidelines
KW - MIRD
KW - Radioiodine
UR - http://www.scopus.com/inward/record.url?scp=84921891335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921891335&partnerID=8YFLogxK
U2 - 10.5603/NMR.2015.0004
DO - 10.5603/NMR.2015.0004
M3 - Article
VL - 18
SP - 13
EP - 18
JO - Nuclear Medicine Review
JF - Nuclear Medicine Review
SN - 1506-9680
IS - 1
ER -