A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment

Andrea Skanjeti, Anna Miranti, Gabriela Mariam Delgado Yabar, Davide Bianciotto, Edoardo Trevisiol, Michele Stasi, Valerio Podio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3% higher in Graves' disease (p = 0.001) and 3% higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33% in Graves' disease; 17% in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20%; 42% in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalNuclear Medicine Review
Volume18
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Thyroid Nodule
Graves Disease
Hyperthyroidism
Nuclear Medicine
Guidelines
Therapeutics

Keywords

  • Autonomous thyroid nodule
  • Graves' disease
  • Guidelines
  • MIRD
  • Radioiodine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Skanjeti, A., Miranti, A., Yabar, G. M. D., Bianciotto, D., Trevisiol, E., Stasi, M., & Podio, V. (2015). A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment. Nuclear Medicine Review, 18(1), 13-18. https://doi.org/10.5603/NMR.2015.0004

A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment. / Skanjeti, Andrea; Miranti, Anna; Yabar, Gabriela Mariam Delgado; Bianciotto, Davide; Trevisiol, Edoardo; Stasi, Michele; Podio, Valerio.

In: Nuclear Medicine Review, Vol. 18, No. 1, 2015, p. 13-18.

Research output: Contribution to journalArticle

Skanjeti, A, Miranti, A, Yabar, GMD, Bianciotto, D, Trevisiol, E, Stasi, M & Podio, V 2015, 'A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment', Nuclear Medicine Review, vol. 18, no. 1, pp. 13-18. https://doi.org/10.5603/NMR.2015.0004
Skanjeti, Andrea ; Miranti, Anna ; Yabar, Gabriela Mariam Delgado ; Bianciotto, Davide ; Trevisiol, Edoardo ; Stasi, Michele ; Podio, Valerio. / A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment. In: Nuclear Medicine Review. 2015 ; Vol. 18, No. 1. pp. 13-18.
@article{d74e65d4a44c494699fe203e6ecd6f95,
title = "A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment",
abstract = "BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3{\%} higher in Graves' disease (p = 0.001) and 3{\%} higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33{\%} in Graves' disease; 17{\%} in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20{\%}; 42{\%} in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.",
keywords = "Autonomous thyroid nodule, Graves' disease, Guidelines, MIRD, Radioiodine",
author = "Andrea Skanjeti and Anna Miranti and Yabar, {Gabriela Mariam Delgado} and Davide Bianciotto and Edoardo Trevisiol and Michele Stasi and Valerio Podio",
year = "2015",
doi = "10.5603/NMR.2015.0004",
language = "English",
volume = "18",
pages = "13--18",
journal = "Nuclear Medicine Review",
issn = "1506-9680",
publisher = "Via Medica",
number = "1",

}

TY - JOUR

T1 - A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment

AU - Skanjeti, Andrea

AU - Miranti, Anna

AU - Yabar, Gabriela Mariam Delgado

AU - Bianciotto, Davide

AU - Trevisiol, Edoardo

AU - Stasi, Michele

AU - Podio, Valerio

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3% higher in Graves' disease (p = 0.001) and 3% higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33% in Graves' disease; 17% in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20%; 42% in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.

AB - BACKGROUND: Aim of the study was to evaluate accuracy of different dosimetry protocols in estimating the required 131I activity to treat hyperthyroid patients. MATERIALS AND METHODS: Forty consecutive patients were analysed: twenty-eight Graves' disease; twelve autonomous thyroid nodule (ATN). Maximum-uptake, effective half-time and residence-time were estimated from Radioiodine Uptake Test. Residence-time was estimated using a bi-compartmental model. For 131I activity calculation, algorithms laid down in European Association of Nuclear Medicine (EANM) guidelines, ICRP 53 approach and a mono-exponential formula (ME), were compared with OLINDA/EXM results. Results: Based on EANM guidelines, activities to be administered were 3% higher in Graves' disease (p = 0.001) and 3% higher in ATN (p = 0.046). Calculated activities using ICRP 53 approach were significantly lower compared to OLINDA/EXM: 33% in Graves' disease; 17% in ATN. Activities recommended by ME, were significantly higher: in Graves' disease 20%; 42% in ATN. CONCLUSIONS: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.

KW - Autonomous thyroid nodule

KW - Graves' disease

KW - Guidelines

KW - MIRD

KW - Radioiodine

UR - http://www.scopus.com/inward/record.url?scp=84921891335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921891335&partnerID=8YFLogxK

U2 - 10.5603/NMR.2015.0004

DO - 10.5603/NMR.2015.0004

M3 - Article

VL - 18

SP - 13

EP - 18

JO - Nuclear Medicine Review

JF - Nuclear Medicine Review

SN - 1506-9680

IS - 1

ER -