A simple loop method for the automated preparation of [11C]raclopride from [11C]methyl triflate

R. Iwata, C. Pascali, A. Bogni, Y. Miyake, K. Yanai, T. Ido

Research output: Contribution to journalArticlepeer-review

Abstract

A simple automated preparation of [11C]raclopride by reaction of [11C]methyl triflate with demethylraclopride triflate is described. The conventional bubbling of [11C]methyl triflate into the precursor solution was compared with two alternative methods which used a commercially available C18 cartridge (on-column method) or an empty PTFE tube (loop method) as support for the precursor solution. The influence of several solvents was assessed for all three methods. The on-column method showed excellent trapping efficiencies of [11C]methyl triflate but gave the lowest radiochemical yields. The loop method proved to be a simplified alternative to the bubbling method, giving comparable radiochemical yields with less precursor and offering an easy way to transfer the reaction mixture into an HPLC column. By the simple-loop method [11C]raclopride could be prepared in over 40% radiochemical yields (decay-corrected and based on [11C]methyl triflate).

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalApplied Radiation and Isotopes
Volume55
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • [C]Methyl triflate
  • [C]Raclopride
  • Automated synthesis
  • Carbon-11
  • Loop [C]methylation method
  • PET

ASJC Scopus subject areas

  • Radiation

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