A simple prognostic scoring system for newly diagnosed cytogenetically normal acute myeloid leukemia: Retrospective analysis of 530 patients

Michele Malagola, Cristina Skert, Marco Vignetti, Alfonso Piciocchi, Giovanni Martinelli, Giuliana Alimena, Cristina Mecucci, Nicoletta Testoni, Ilaria Iacobucci, Marino Clavio, Marco Gobbi, Anna Candoni, Daniela Damiani, Monica Bocchia, Francesco Lauria, Alfonso Zaccaria, Patrizio Mazza, Giuseppe Visani, Annalisa Peli, Chiara ColombiValeria Cancelli, Marco Mancini, Robin Fo, Massimo Martelli, Nicola Cantore, Francesco Di Raimondo, Mario Petrini, Paolo De Fabritiis, Giuseppe Fioritoni, Francesco Nobile, Francesco Fabbiano, Giorgina Specchia, Michele Baccarani, Francesco Lo Coco, Sergio Amadori, Franco Mandelli, Domenico Russo

Research output: Contribution to journalArticle

Abstract

We retrospectively analyzed the data of 337 patients with cytogenetically normal (CN) acute myeloid leukemia (AML), aged ≤ 65 years (training set). A prognostic index score (PIS) was calculated by totaling the score derived from the regression coefficients of each clinical variable, significantly associated with prognosis by multivariate analysis. The variables that were independent prognostic factors for event-free survival (EFS) and overall survival (OS) in the training set were: age ≥ 50 years, secondary AML and white blood cell count (WBC) ≥ 20 × 10 9/L. The patients of the training set were stratified into three groups: low-, intermediate-and high-risk. The median EFS was 25, 12 and 7 months in the low-, intermediate-and high-risk groups (p <0.0001), respectively. The median OS was not reached in the low-risk group and was 19 and 10 months in the intermediate-and high-risk groups (p <0.0001). This PIS was validated in a series of 193 patients with CN-AML. The median EFS was 66, 16, and 3 months (p <0.0001) and the median OS was 66, 16, and 5 months in the three risk groups, respectively (p <0.0001). This PIS may be useful for clinical decision-making in CN-AML and may be prospectively integrated with the newest biological markers which at present are not routinely assessed and need prognostic validation.

Original languageEnglish
Pages (from-to)2329-2335
Number of pages7
JournalLeukemia and Lymphoma
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Acute leukemia
  • Cytogenetics
  • Prognostic factors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Malagola, M., Skert, C., Vignetti, M., Piciocchi, A., Martinelli, G., Alimena, G., Mecucci, C., Testoni, N., Iacobucci, I., Clavio, M., Gobbi, M., Candoni, A., Damiani, D., Bocchia, M., Lauria, F., Zaccaria, A., Mazza, P., Visani, G., Peli, A., ... Russo, D. (2011). A simple prognostic scoring system for newly diagnosed cytogenetically normal acute myeloid leukemia: Retrospective analysis of 530 patients. Leukemia and Lymphoma, 52(12), 2329-2335. https://doi.org/10.3109/10428194.2011.596965