A simple role for BDNF in learning and memory?

Carla Cunha, Riccardo Brambilla, Kerrie L. Thomas

Research output: Contribution to journalArticlepeer-review


Since its discovery almost three decades ago, the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of neurons of the CNS. More recently, BDNF has also emerged as an important regulator of synaptogenesis and synaptic plasticity mechanisms underlying learning and memory in the adult CNS. In this review we will discuss our knowledge about the multiple intracellular signaling pathways activated by BDNF, and the role of this neurotrophin in long-term synaptic plasticity and memory formation as well as in synaptogenesis. We will show that maturation of BDNF, its cellular localization and its ability to regulate both excitatory and inhibitory synapses in the CNS may result in confl icting alterations in synaptic plasticity and memory formation. Lack of a precise knowledge about the mechanisms by which BDNF infl uences higher cognitive functions and complex behaviours may constitute a severe limitation in the possibility to devise BDNF-based therapeutics for human disorders of the CNS.

Original languageEnglish
JournalFrontiers in Molecular Neuroscience
Publication statusPublished - 2010


  • BDNF
  • Behavior
  • Cell signalling
  • Learning and memory
  • Synaptic plasticity
  • Synaptogenesis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology


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