A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues

Siddharth Bommakanti, Poornima Agoramurthy, Luca Campana, Raji Sundararajan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Effective Electrochemotherapy is possible with suitable multi-electrode needle array geometries, especially to treat larger areas, such as thigh and chest. This is critical to expedite the application of electrical pulses at the tumor area within a few minutes, after injection of the chemo drug, such as bleomycin, at the tumor, intratumorally or intravenously. To study the efficiency of larger electrode arrays, it is necessary to analyze their electric field distributions. This can be done by designing an effective model with electric needles so that an electric field of 1200 volts/cm could be generated at the point of tumor. To simulate these models with various configurations of electric needles, Maxwell 13 software was used. All the models were implemented in 2-D analysis. Several models with various number of electrodes were studied, including 2×2, 4×2, 4×4, and 1×22 configurations. The simulation results show uniform electric field over the desired area. The significance of this research is that using novel, multi-electrode needle arrays, a larger area of the cancer affected tissue can be treated faster than currently used 4mm needle arrays.

Original languageEnglish
Title of host publicationAnnual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP
Pages187-190
Number of pages4
DOIs
Publication statusPublished - 2011
Event2011 Annual Report Conference on Electrical Insulation and Dielectric Phenomena, CEIDP 2011 - Cancun, Mexico
Duration: Oct 16 2011Oct 19 2011

Other

Other2011 Annual Report Conference on Electrical Insulation and Dielectric Phenomena, CEIDP 2011
CountryMexico
CityCancun
Period10/16/1110/19/11

Fingerprint

Needles
Tissue
Electrodes
Tumors
Electric fields
Bleomycin
Geometry
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

Cite this

Bommakanti, S., Agoramurthy, P., Campana, L., & Sundararajan, R. (2011). A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. In Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP (pp. 187-190). [6232628] https://doi.org/10.1109/CEIDP.2011.6232628

A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. / Bommakanti, Siddharth; Agoramurthy, Poornima; Campana, Luca; Sundararajan, Raji.

Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP. 2011. p. 187-190 6232628.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bommakanti, S, Agoramurthy, P, Campana, L & Sundararajan, R 2011, A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. in Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP., 6232628, pp. 187-190, 2011 Annual Report Conference on Electrical Insulation and Dielectric Phenomena, CEIDP 2011, Cancun, Mexico, 10/16/11. https://doi.org/10.1109/CEIDP.2011.6232628
Bommakanti S, Agoramurthy P, Campana L, Sundararajan R. A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. In Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP. 2011. p. 187-190. 6232628 https://doi.org/10.1109/CEIDP.2011.6232628
Bommakanti, Siddharth ; Agoramurthy, Poornima ; Campana, Luca ; Sundararajan, Raji. / A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP. 2011. pp. 187-190
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