A simulation environment for directional sensing as a phase separation process.

Antonio de Candia, Andrea Gamba, Fausto Cavalli, Antonio Coniglio, Stefano Di Talia, Federico Bussolino, Guido Serini

Research output: Contribution to journalArticle

Abstract

The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

Original languageEnglish
JournalScience's STKE : signal transduction knowledge environment
Volume2007
Issue number378
DOIs
Publication statusPublished - Apr 7 2007

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Chemotactic Factors
Eukaryotic Cells
Chemotaxis
Spatio-Temporal Analysis
Aptitude
Phosphatidylinositols
Computer Simulation
Embryonic Development
Cues
Regeneration
Software
Cell Membrane
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A simulation environment for directional sensing as a phase separation process. / de Candia, Antonio; Gamba, Andrea; Cavalli, Fausto; Coniglio, Antonio; Di Talia, Stefano; Bussolino, Federico; Serini, Guido.

In: Science's STKE : signal transduction knowledge environment, Vol. 2007, No. 378, 07.04.2007.

Research output: Contribution to journalArticle

de Candia, Antonio ; Gamba, Andrea ; Cavalli, Fausto ; Coniglio, Antonio ; Di Talia, Stefano ; Bussolino, Federico ; Serini, Guido. / A simulation environment for directional sensing as a phase separation process. In: Science's STKE : signal transduction knowledge environment. 2007 ; Vol. 2007, No. 378.
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