A single blind comparison of dihydroergotoxine mesilate and clonidine for treatment of hypertensive emergencies

E. Guffanti, A. Vaccarella, M. Meregalli, G. Fiorella, S. M. Chierichetti, C. Mazzola

Research output: Contribution to journalArticlepeer-review

Abstract

The effectiveness and safety of dihydroergotoxine mesylate (DHT) and clonidine (CLO) as acute antihypertensive treatments were studied in a single-blind randomized controlled study of 28 patients hospitalized after abrupt increases in mean blood pressure (MAP) to more than 150 mmHg, with concomitant symptoms related to hypertensive status (16 patients). Intravenous infusion of 1.5 mg DHT significantly reduced both systolic (SBP) and diastolic (DBP) blood pressure from 227 ± 2/128 ± 2 mmHg to 160 ± 4/94 ± 2 mmHg by 1 hour after the onset of infusion (p

Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume23
Issue number9
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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