A Soluble Form of CTLA-4 Is Present in Paediatric Patients with Acute Lymphoblastic Leukaemia and Correlates with CD1d+ Expression

Rita Simone; Claudya Tenca; Franco Fais; Matteo Luciani; Giulio de Rossi; Giampaola Pesce; Marcello Bagnasco; Daniele Saverino

doi:10.1371/journal.pone.0044654

A Soluble Form of CTLA-4 Is Present in Paediatric Patients with Acute Lymphoblastic Leukaemia and Correlates with CD1d+ Expression

Rita Simone, Claudya Tenca, Franco Fais, Matteo Luciani, Giulio de Rossi, Giampaola Pesce, Marcello Bagnasco, Daniele Saverino

Research output: Contribution to journal › Article › peer-review

Abstract

CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susceptibility to human cancer. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence at significantly elevated levels of a circulating soluble form of CTLA-4 in 70% of B-ALL pediatric patients with active disease, the positive correlation between the percentage of leukemic B lymphocytes and the amount of serum sCTLA-4, and the expression of sCTLA-4 transcript by B cells in patients. Finally, a correlation between CD1d expression (a negative prognostic marker) and the sCTLA-4 in B-ALL patients was observed. This suggests a possible role of this soluble molecule as a marker of progression or severity of the neoplastic disease.

Original language	English
Article number	e44654
Journal	PLoS One
Volume	7
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0044654
Publication status	Published - Sep 25 2012

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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A Soluble Form of CTLA-4 Is Present in Paediatric Patients with Acute Lymphoblastic Leukaemia and Correlates with CD1d+ Expression. / Simone, Rita; Tenca, Claudya; Fais, Franco ; Luciani, Matteo; de Rossi, Giulio; Pesce, Giampaola; Bagnasco, Marcello; Saverino, Daniele.

In: PLoS One, Vol. 7, No. 9, e44654, 25.09.2012.

Research output: Contribution to journal › Article › peer-review

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