TY - JOUR
T1 - A special case of medicine in disguise
T2 - Tattoo inks containing anaesthetics
AU - Manna, Livia
AU - Gaudiano, Maria Cristina
AU - Bartolomei, Monica
AU - Valvo, Luisa
AU - Bertocchi, Paola
AU - Antoniella, Eleonora
AU - Rodomonte, Andrea Luca
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - This paper describes a case of medicine in disguise: seized tattoo inks containing lidocaine and tetracaine at high concentration. Identification of anaesthetics was performed by LC MS Q-TOF with ESI+ source, by accurate mass measurement and by comparing the fragmentation patterns of molecular ions, at 30 V and 10 V of collision-offset voltage, with reference standards. Quantification was also performed by LC MS Q-TOF on the chromatographic peaks in the extracted ion chromatograms, by calibration curves obtained at different standard concentrations and by standard additions approach. The measurement uncertainty was estimated from validation data. The paper gives also chromatographic parameters, MS and MS/MS data and a quantitation method, with a full validation, of other six "caines". Thus the paper intends to provide a tool for identification and quantitation of the most common local anaesthetics that could be fraudulently added to tattoo inks. The results here reported show that the seized samples of inks represent a serious health risk owing to the high anaesthetic content - therapeutic-like dosage - found.
AB - This paper describes a case of medicine in disguise: seized tattoo inks containing lidocaine and tetracaine at high concentration. Identification of anaesthetics was performed by LC MS Q-TOF with ESI+ source, by accurate mass measurement and by comparing the fragmentation patterns of molecular ions, at 30 V and 10 V of collision-offset voltage, with reference standards. Quantification was also performed by LC MS Q-TOF on the chromatographic peaks in the extracted ion chromatograms, by calibration curves obtained at different standard concentrations and by standard additions approach. The measurement uncertainty was estimated from validation data. The paper gives also chromatographic parameters, MS and MS/MS data and a quantitation method, with a full validation, of other six "caines". Thus the paper intends to provide a tool for identification and quantitation of the most common local anaesthetics that could be fraudulently added to tattoo inks. The results here reported show that the seized samples of inks represent a serious health risk owing to the high anaesthetic content - therapeutic-like dosage - found.
KW - Anesthetics/analysis
KW - Chromatography, Liquid
KW - Humans
KW - Ink
KW - Lidocaine/analysis
KW - Mass Spectrometry
KW - Tattooing
KW - Tetracaine/analysis
U2 - 10.1016/j.talanta.2019.02.033
DO - 10.1016/j.talanta.2019.02.033
M3 - Article
C2 - 30876570
VL - 198
SP - 337
EP - 343
JO - Talanta
JF - Talanta
SN - 0039-9140
ER -