A stage-for-stage and grade-for-grade analysis of cancer-specific mortality rates in renal cell carcinoma according to age: A competing-risks regression analysis

Maxine Sun, Firas Abdollah, Marco Bianchi, Quoc Dien Trinh, Claudio Jeldres, Zhe Tian, Shahrokh F. Shariat, Hugues Widmer, Kevin Zorn, Mani Menon, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

Background: The association of advanced age and cancer control outcomes shows discordant findings. Objective: To evaluate the effect of age on cancer control outcomes in a large population-based cohort of patients diagnosed with renal cell carcinoma (RCC) of all stages. Design, setting, and participants: Using the Surveillance Epidemiology and End Results database, 36 333 patients with RCC were identified. The population was stratified according to age: <50, 50-59, 60-69, 70-79, and ≥80 yr. The effect of age on cancer control outcomes was evaluated using competing-risks regression models. Analyses were repeated stage for stage and grade for grade. Measurements: Cancer-specific mortality (CSM) was measured. Results and limitations: Age categories 50-59, 60-69, 70-79, and ≥80 yr respectively portended a 1.4-, 1.5-, 1.6-, and 1.9-fold higher risk of CSM than age category

Original languageEnglish
Pages (from-to)1152-1159
Number of pages8
JournalEuropean Urology
Volume60
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Age
  • Cancer-specific mortality
  • Competing-risks regression
  • Nephrectomy
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

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    Sun, M., Abdollah, F., Bianchi, M., Trinh, Q. D., Jeldres, C., Tian, Z., Shariat, S. F., Widmer, H., Zorn, K., Menon, M., Montorsi, F., Perrotte, P., & Karakiewicz, P. I. (2011). A stage-for-stage and grade-for-grade analysis of cancer-specific mortality rates in renal cell carcinoma according to age: A competing-risks regression analysis. European Urology, 60(6), 1152-1159. https://doi.org/10.1016/j.eururo.2011.07.064