A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

Josbert J Keller, Rogier E Ooijevaar, Christian L Hvas, Elisabeth M Terveer, Simone C Lieberknecht, Christoph Högenauer, Perttu Arkkila, Harry Sokol, Oleksiy Gridnyev, Francis Mégraud, Patrizia K Kump, Radislav Nakov, Simon D Goldenberg, Reetta Satokari, Sergiy Tkatch, Maurizio Sanguinetti, Giovanni Cammarota, Andrey Dorofeev, Olena Gubska, Gianluca IaniroEero Mattila, Ramesh P Arasaradnam, Shiv K Sarin, Ajit Sood, Lorenza Putignani, Laurent Alric, Simon Md Baunwall, Juozas Kupcinskas, Alexander Link, Abraham G Goorhuis, Hein W Verspaget, Cyriel Ponsioen, Georgina L Hold, Herbert Tilg, Zain Kassam, Ed J Kuijper, Antonio Gasbarrini, Chris Jj Mulder, Horace Rt Williams, Maria Jgt Vehreschild

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Fecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of feces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council.

OBJECTIVE: Several European and international consensus statements concerning fecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document.

METHODS: Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about fecal microbiota transplantation.

RESULTS: A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening.

CONCLUSION: The implementation of fecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor feces preparations for patients.

Original languageEnglish
Pages (from-to)2050640620967898
JournalUnited European Gastroenterology Journal
DOIs
Publication statusE-pub ahead of print - Nov 5 2020

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