A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Francesca Nardelli, Michela Ghitti, Giacomo Quilici, Alessandro Gori, Qingqiong Luo, Andrea Berardi, Angelina Sacchi, Matteo Monieri, Greta Bergamaschi, Wolfgang Bermel, Fuxiang Chen, Angelo Corti, Flavio Curnis, Giovanna Musco

Research output: Contribution to journalArticle

Abstract

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.

Original languageEnglish
Pages (from-to)14777-14780
Number of pages4
JournalChemical Communications
Volume55
Issue number98
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Nardelli, F., Ghitti, M., Quilici, G., Gori, A., Luo, Q., Berardi, A., Sacchi, A., Monieri, M., Bergamaschi, G., Bermel, W., Chen, F., Corti, A., Curnis, F., & Musco, G. (2019). A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8. Chemical Communications, 55(98), 14777-14780. https://doi.org/10.1039/c9cc08518a