A structured framework for optimizing high-intensity focused ultrasound ablative treatment in localized prostate cancer

Daniele Castellani, Alessandro Branchi, Redi Claudini, Luca Gasparri, Tiziana Pierangeli, Elena Ravasi, Marco Dellabella

Research output: Contribution to journalArticle


High-intensity focused ultrasound (HIFU) treatment has recently been pursued to reduce radical treatment-related morbidity in low-to-intermediate-risk localized prostate cancer (PCa), especially in older men. The aim of this study was to develop a dedicated framework for HIFU therapy. All clinical data, such as risk categories, magnetic resonance with functional parametric imaging, and histopathology, are essential for driving proper HIFU treatment. All needed data can be added to the framework to localize areas that need to be treated. Once PCa areas have been featured, quantified, and located, planning can be adapted to drive accurate HIFU treatment. Our planning framework may be useful for all ablative therapies in order to standardize treatment for both clinical and scientific purposes.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalInvestigative and Clinical Urology
Issue number4
Publication statusPublished - Jan 1 2019



  • Ablation techniques
  • High-intensity focused ultrasound ablation
  • Planning techniques
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

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