A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease

Geoffroy Laumet, Vincent Petitprez, Adeline Sillaire, Anne Marie Ayral, Franck Hansmannel, Julien Chapuis, Didier Hannequin, Florence Pasquier, Elio Scarpini, Daniela Galimberti, Corinne Lendon, Dominique Campion, Philippe Amouyel, Jean Charles Lambert

Research output: Contribution to journalArticlepeer-review

Abstract

Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to β-amyloid (Aβ) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Aβ. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalNeuroscience Letters
Volume468
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

Keywords

  • ADAM12
  • Alzheimer's disease
  • Association study
  • Polymorphism
  • SH3PXD2A

ASJC Scopus subject areas

  • Neuroscience(all)

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