A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients

Arianna Vignini, Laura Nanetti, Cinzia Moroni, Roberto Testa, Cristina Sirolla, Maurizio Marra, Silvana Manfrini, Daniele Fumelli, Fiorella Marcheselli, Laura Mazzanti, Rosa Anna Rabini

Research output: Contribution to journalArticle

Abstract

Background and aim: Type 2 diabetic (T2DM) patients show decreased fibrinolysis, mainly linked to high plasminogen activator inhibitor type 1 (PAI-1) production, together with a reduced bioavailability of nitric oxide and an impairment in Na+/K+-ATPase activity possibly involved in increased cardiovascular risk. Vitamin E is the major natural lipid-soluble antioxidant in human plasma. The present work was conducted in order to measure PAI-1, ICAM and VCAM-1 plasma levels, platelet nitric oxide production and membrane Na+/K+-ATPase activity in type 2 diabetic subjects treated with vitamin E (500 IU/day) for 10 weeks and then followed for other 20 weeks. Methods and results: Thirty-seven T2DM patients (24 males and 13 females) were studied. None of them were affected by any other disease or diabetic complications. Significant differences were detected for PAI-1 antigen (p <0.001), PAI-1 activity (p <0.001), nitric oxide (NO) production (p <0.001), and Na+/K+-ATPase activity (p <0.001) among the 4 phases of the study. A significant decrease both in ICAM and VCAM-1 plasma levels was also found at the 10th week compared with baseline (respectively p <0.001 and p <0.05). Conclusion: Our data suggest that vitamin E counteracts endothelial activation in T2DM patients possibly representing a new tool for endothelial protection.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Na/K-ATPase
  • Nitric oxide
  • Plasminogen activator inhibitor type 1
  • Type 2 diabetes mellitus
  • Vitamin E

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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