A study on the biological behavior of human brain tumors Part I. Arachidonic acid metabolism and DNA content

Paolo Gaetanil, Giorgio Butti, Chiara Chiabrando, Marco Danova, Maria Grazia Castelli, Alberto Riccardi, Roberto Assietti, Pietro Paolettil

Research output: Contribution to journalArticle

Abstract

The study of proliferative characteristics and biochemical aspects seem to be of great importance in order to define brain neoplastic behavior. The purpose of this study is to verify the existence of any possible correlation between Arachidonic Acid (AA) metabolism and proliferative characteristics in 30 meningiomas and 30 neuroepithelial tumors. The most represented metabolite in neuroepithelial tumors is TxB2, while 6-Keto-PGF is the lowest represented product. Unimodal DNA distribution was observed in 66% of neuroepithelial tumors and in 87% of meningiomas. Aneuploidy was more frequent in glioblastomas and anaplastic meningiomas as previously reported; AA overall synthesis capacity and profile were similar between unimodal and bimodal cases of neuroepithelial tumors. Total AA metabolite, as well as TxB2 and PGD2, synthesis capacity are significantly higher in cases with S-phase cell percentage ≥ 3% than in cases with S-phase % <3%. Total production of AA metabolites via the cyclooxygenase pathway is significantly higher in meningiomas with bimodal DNA distribution than in cases with unimodal DNA content; when considering S-phase cell percentage, similarly to what observed in neuroepithelial tumors, meningiomas with S% > 3% shows a significantly higher overall synthesis capacity for AA. AA metabolism capacity well correlates with proliferative patterns in neuroepithelial tumors: the relationship depends preferentially on TxB2 and PGD2 synthesis capacity. In cases of meningiomas, the amount of AA metabolites seem to be related to DNA content and proliferative activity when anaplastic features are histologically demonstrated.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalJournal of Neuro-Oncology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 1991

Fingerprint

Neuroepithelial Neoplasms
Arachidonic Acid
Brain Neoplasms
Meningioma
DNA
Prostaglandin D2
S Phase
Aneuploidy
Glioblastoma
Brain

Keywords

  • arachidonic acid
  • brain tumors
  • cell kinetics
  • prostaglandins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Gaetanil, P., Butti, G., Chiabrando, C., Danova, M., Castelli, M. G., Riccardi, A., ... Paolettil, P. (1991). A study on the biological behavior of human brain tumors Part I. Arachidonic acid metabolism and DNA content. Journal of Neuro-Oncology, 10(3), 233-240. https://doi.org/10.1007/BF00177535

A study on the biological behavior of human brain tumors Part I. Arachidonic acid metabolism and DNA content. / Gaetanil, Paolo; Butti, Giorgio; Chiabrando, Chiara; Danova, Marco; Castelli, Maria Grazia; Riccardi, Alberto; Assietti, Roberto; Paolettil, Pietro.

In: Journal of Neuro-Oncology, Vol. 10, No. 3, 06.1991, p. 233-240.

Research output: Contribution to journalArticle

Gaetanil, P, Butti, G, Chiabrando, C, Danova, M, Castelli, MG, Riccardi, A, Assietti, R & Paolettil, P 1991, 'A study on the biological behavior of human brain tumors Part I. Arachidonic acid metabolism and DNA content', Journal of Neuro-Oncology, vol. 10, no. 3, pp. 233-240. https://doi.org/10.1007/BF00177535
Gaetanil, Paolo ; Butti, Giorgio ; Chiabrando, Chiara ; Danova, Marco ; Castelli, Maria Grazia ; Riccardi, Alberto ; Assietti, Roberto ; Paolettil, Pietro. / A study on the biological behavior of human brain tumors Part I. Arachidonic acid metabolism and DNA content. In: Journal of Neuro-Oncology. 1991 ; Vol. 10, No. 3. pp. 233-240.
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