A study on the biological behavior of human brain tumors Part II: Steroid receptors and arachidonic acid metabolism

Giorgio Butti, Paolo Gaetani, Chiara Chiabrando, Roberto Assietti, Carlo Zibera, Maria Grazia Castelli, Nadia Gibelli, Vittorio Silvani, Gioacchino Robustelli della Cuna, Pietro Paoletti

Research output: Contribution to journalArticle

Abstract

The significance of steroid receptors (SR) in human brain tumors is presently a field of intense investigation in order to clarify some aspects of the biological behavior of these neoplasms. We studied the relationship between the presence of steroid receptors and the production of metabolites of the arachidonic acid cascade which have been reported to have a role in the biological behavior of some human tumors. We found that some metabolites of arachidonic acid are produced in different amounts in brain tumors which either did or did not express some steroid receptors. In particular the PGE2 were higher in estrogen receptors (ER) positive meningiomas than in ER negative ones and 6-keto-PGF, the stable metabolite of prostacyclin, is significantly higher in androgen receptors (AR) negative meningiomas than in AR positive ones. In neuroepithelial tumors the glucocorticoid receptors (GR) positive cases synthesized more TxB2 and less PGE2 than the GR negative ones. Our data seem to suggest that some correlations exist between the presence of some steroid receptors and arachidonic acid metabolite production.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalJournal of Neuro-Oncology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 1991

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Keywords

  • arachidonic acid
  • meningioma
  • neuroepithelial tumors
  • steroid receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Butti, G., Gaetani, P., Chiabrando, C., Assietti, R., Zibera, C., Castelli, M. G., Gibelli, N., Silvani, V., Robustelli della Cuna, G., & Paoletti, P. (1991). A study on the biological behavior of human brain tumors Part II: Steroid receptors and arachidonic acid metabolism. Journal of Neuro-Oncology, 10(3), 241-246. https://doi.org/10.1007/BF00177536