A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12

Adewale Adeyinka; Nikos Pandis; Georgia Bardi; Laura Bonaldi; Fredrik Mertens; Felix Mitelman; Sverre Heim

doi:10.1016/S0165-4608(96)00390-1

A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12

Adewale Adeyinka, Nikos Pandis, Georgia Bardi, Laura Bonaldi, Fredrik Mertens, Felix Mitelman, Sverre Heim

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Chrosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had + 12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These indings, especially when coupled with similar information on previously published cases, show that gain of choromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.

Original language	English
Pages (from-to)	119-121
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	97
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(96)00390-1
Publication status	Published - Sep 1997

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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abstract = "Chrosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had + 12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These indings, especially when coupled with similar information on previously published cases, show that gain of choromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.",

author = "Adewale Adeyinka and Nikos Pandis and Georgia Bardi and Laura Bonaldi and Fredrik Mertens and Felix Mitelman and Sverre Heim",

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AU - Adeyinka, Adewale

AU - Pandis, Nikos

AU - Bardi, Georgia

AU - Bonaldi, Laura

AU - Mertens, Fredrik

AU - Mitelman, Felix

AU - Heim, Sverre

PY - 1997/9

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AB - Chrosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had + 12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These indings, especially when coupled with similar information on previously published cases, show that gain of choromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.

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