TY - JOUR
T1 - A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12
AU - Adeyinka, Adewale
AU - Pandis, Nikos
AU - Bardi, Georgia
AU - Bonaldi, Laura
AU - Mertens, Fredrik
AU - Mitelman, Felix
AU - Heim, Sverre
PY - 1997/9
Y1 - 1997/9
N2 - Chrosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had + 12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These indings, especially when coupled with similar information on previously published cases, show that gain of choromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.
AB - Chrosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had + 12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These indings, especially when coupled with similar information on previously published cases, show that gain of choromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.
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U2 - 10.1016/S0165-4608(96)00390-1
DO - 10.1016/S0165-4608(96)00390-1
M3 - Article
C2 - 9283594
AN - SCOPUS:0030802965
VL - 97
SP - 119
EP - 121
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -