A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12

Adewale Adeyinka, Nikos Pandis, Georgia Bardi, Laura Bonaldi, Fredrik Mertens, Felix Mitelman, Sverre Heim

Research output: Contribution to journalArticlepeer-review

Abstract

Chrosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had + 12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These indings, especially when coupled with similar information on previously published cases, show that gain of choromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume97
Issue number2
DOIs
Publication statusPublished - Sep 1997

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Fingerprint Dive into the research topics of 'A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12'. Together they form a unique fingerprint.

Cite this