A subset of genetic susceptibility variants for colorectal cancer also has prognostic value

S. Noci, M. Dugo, F. Bertola, F. Melotti, A. Vannelli, T. A. Dragani, A. Galvan

Research output: Contribution to journalArticle

Abstract

We investigated the possible influence of 86 single-nucleotide polymorphisms (SNPs), known to associate with the risk of colorectal cancer (CRC), on overall survival and time to recurrence (TTR) in 733 Italian CRC patients followed up for up to 84 months after surgery. In the Cox multivariate analysis, adjusted for gender, age, pathological stage and adjuvant chemotherapy (yes/no), the risk of death significantly increased by rare allele count (P

Original languageEnglish
JournalPharmacogenomics Journal
DOIs
Publication statusAccepted/In press - May 12 2015

Fingerprint

Genetic Predisposition to Disease
Colorectal Neoplasms
Adjuvant Chemotherapy
Single Nucleotide Polymorphism
Multivariate Analysis
Alleles
Recurrence
Survival

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics

Cite this

A subset of genetic susceptibility variants for colorectal cancer also has prognostic value. / Noci, S.; Dugo, M.; Bertola, F.; Melotti, F.; Vannelli, A.; Dragani, T. A.; Galvan, A.

In: Pharmacogenomics Journal, 12.05.2015.

Research output: Contribution to journalArticle

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