A subset of Vγ9Vδ2 T cells help B cells for antibody production

N. Caccamo, S. Meraviglia, C. La Mendola, S. Buccheri, M. D'Asaro, Francesco Dieli, A. Salerno

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in antibody-mediated immune responses. Here we report on the identification of a unique subset of Vγ9Vδ2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4 and IL-10 and help B cells for antibody production. These properties portray CXCR5+ Vγ9Vδ2 T cells as a distinct memory T cell subset with B cell helper function.

Original languageEnglish
Pages (from-to)10-13
Number of pages4
JournalHaematologica Reports
Volume2
Issue number3
Publication statusPublished - 2006

Fingerprint

T-Lymphocyte Subsets
Antibody Formation
B-Lymphocytes
T-Lymphocytes
CD40 Ligand
Cellular Immunity
Interleukin-4
Interleukin-10
Interleukin-2
Antigens
Antibodies
Neoplasms

Keywords

  • Antibody production
  • B-cell help
  • CXCR5
  • HIV infection
  • Vγ9Vδ2 T cells

ASJC Scopus subject areas

  • Hematology

Cite this

Caccamo, N., Meraviglia, S., La Mendola, C., Buccheri, S., D'Asaro, M., Dieli, F., & Salerno, A. (2006). A subset of Vγ9Vδ2 T cells help B cells for antibody production. Haematologica Reports, 2(3), 10-13.

A subset of Vγ9Vδ2 T cells help B cells for antibody production. / Caccamo, N.; Meraviglia, S.; La Mendola, C.; Buccheri, S.; D'Asaro, M.; Dieli, Francesco; Salerno, A.

In: Haematologica Reports, Vol. 2, No. 3, 2006, p. 10-13.

Research output: Contribution to journalArticle

Caccamo, N, Meraviglia, S, La Mendola, C, Buccheri, S, D'Asaro, M, Dieli, F & Salerno, A 2006, 'A subset of Vγ9Vδ2 T cells help B cells for antibody production', Haematologica Reports, vol. 2, no. 3, pp. 10-13.
Caccamo N, Meraviglia S, La Mendola C, Buccheri S, D'Asaro M, Dieli F et al. A subset of Vγ9Vδ2 T cells help B cells for antibody production. Haematologica Reports. 2006;2(3):10-13.
Caccamo, N. ; Meraviglia, S. ; La Mendola, C. ; Buccheri, S. ; D'Asaro, M. ; Dieli, Francesco ; Salerno, A. / A subset of Vγ9Vδ2 T cells help B cells for antibody production. In: Haematologica Reports. 2006 ; Vol. 2, No. 3. pp. 10-13.
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