A subset of Vγ9Vδ2 T cells help B cells for antibody production

N. Caccamo, S. Meraviglia, C. La Mendola, S. Buccheri, M. D'Asaro, Francesco Dieli, A. Salerno

Research output: Contribution to journalArticle

Abstract

Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in antibody-mediated immune responses. Here we report on the identification of a unique subset of Vγ9Vδ2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4 and IL-10 and help B cells for antibody production. These properties portray CXCR5+ Vγ9Vδ2 T cells as a distinct memory T cell subset with B cell helper function.

Original languageEnglish
Pages (from-to)10-13
Number of pages4
JournalHaematologica Reports
Volume2
Issue number3
Publication statusPublished - 2006

Keywords

  • Antibody production
  • B-cell help
  • CXCR5
  • HIV infection
  • Vγ9Vδ2 T cells

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Caccamo, N., Meraviglia, S., La Mendola, C., Buccheri, S., D'Asaro, M., Dieli, F., & Salerno, A. (2006). A subset of Vγ9Vδ2 T cells help B cells for antibody production. Haematologica Reports, 2(3), 10-13.