A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation

Vincenzo Santagada, Francesco Frecentese, Elisa Perissutti, Donatella Cirillo, Sara Terracciano, Giuseppe Caliendo

Research output: Contribution to journalArticlepeer-review


A novel and convenient microwave-assisted synthesis of 1,2,4-oxadiazoles is described. Conventional heating and microwave irradiation of the reactions are compared. Moreover, the importance of some coupling reagents was evaluated. One pot microwave-assisted synthesis of substituted 1,2,4-oxadiazoles in solvent and under solvent free condition was performed exploring the importance of some coupling reagents. Good yields and short reaction times were the main aspects of the methods.

Original languageEnglish
Pages (from-to)4491-4493
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number17
Publication statusPublished - Sep 6 2004


  • 1,2,4-Oxadiazoles
  • Microwave irradiation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science


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