Abstract
A novel and convenient microwave-assisted synthesis of 1,2,4-oxadiazoles is described. Conventional heating and microwave irradiation of the reactions are compared. Moreover, the importance of some coupling reagents was evaluated. One pot microwave-assisted synthesis of substituted 1,2,4-oxadiazoles in solvent and under solvent free condition was performed exploring the importance of some coupling reagents. Good yields and short reaction times were the main aspects of the methods.
| Original language | English |
|---|---|
| Pages (from-to) | 4491-4493 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 14 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Sep 6 2004 |
Keywords
- 1,2,4-Oxadiazoles
- Microwave irradiation
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
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Cite this
Santagada, V., Frecentese, F., Perissutti, E., Cirillo, D., Terracciano, S., & Caliendo, G. (2004). A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation. Bioorganic and Medicinal Chemistry Letters, 14(17), 4491-4493. https://doi.org/10.1016/j.bmcl.2004.06.048