TY - JOUR
T1 - A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI
AU - Tirotta, Ilaria
AU - Mastropietro, Alfonso
AU - Cordiglieri, Chiara
AU - Gazzera, Lara
AU - Baggi, Fulvio
AU - Baselli, Giuseppe
AU - Grazia Bruzzone, Maria
AU - Zucca, Ileana
AU - Cavallo, Gabriella
AU - Terraneo, Giancarlo
AU - Baldelli Bombelli, Francesca
AU - Metrangolo, Pierangelo
AU - Resnati, Giuseppe
PY - 2014/6/18
Y1 - 2014/6/18
N2 - 19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
AB - 19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
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U2 - 10.1021/ja503270n
DO - 10.1021/ja503270n
M3 - Article
C2 - 24884816
AN - SCOPUS:84902667395
VL - 136
SP - 8524
EP - 8527
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 24
ER -