A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

Ilaria Tirotta; Alfonso Mastropietro; Chiara Cordiglieri; Lara Gazzera; Fulvio Baggi; Giuseppe Baselli; Maria Grazia Bruzzone; Ileana Zucca; Gabriella Cavallo; Giancarlo Terraneo; Francesca Baldelli Bombelli; Pierangelo Metrangolo; Giuseppe Resnati

doi:10.1021/ja503270n

A superfluorinated molecular probe for highly sensitive in vivo ¹⁹F-MRI

Ilaria Tirotta, Alfonso Mastropietro, Chiara Cordiglieri, Lara Gazzera, Fulvio Baggi, Giuseppe Baselli, Maria Grazia Bruzzone, Ileana Zucca, Gabriella Cavallo, Giancarlo Terraneo, Francesca Baldelli Bombelli, Pierangelo Metrangolo, Giuseppe Resnati

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

¹⁹F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo ¹⁹F-MRI applications. The molecule, which bears 36 equivalent ¹⁹F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.

Original language	English
Pages (from-to)	8524-8527
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	136
Issue number	24
DOIs	https://doi.org/10.1021/ja503270n
Publication status	Published - Jun 18 2014

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Biochemistry
Colloid and Surface Chemistry
Medicine(all)

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10.1021/ja503270n

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Tirotta, I., Mastropietro, A., Cordiglieri, C., Gazzera, L., Baggi, F., Baselli, G., Grazia Bruzzone, M., Zucca, I., Cavallo, G., Terraneo, G., Baldelli Bombelli, F., Metrangolo, P., & Resnati, G. (2014). A superfluorinated molecular probe for highly sensitive in vivo ¹⁹F-MRI. Journal of the American Chemical Society, 136(24), 8524-8527. https://doi.org/10.1021/ja503270n

A superfluorinated molecular probe for highly sensitive in vivo ¹⁹F-MRI. / Tirotta, Ilaria; Mastropietro, Alfonso; Cordiglieri, Chiara; Gazzera, Lara; Baggi, Fulvio; Baselli, Giuseppe; Grazia Bruzzone, Maria; Zucca, Ileana; Cavallo, Gabriella; Terraneo, Giancarlo; Baldelli Bombelli, Francesca; Metrangolo, Pierangelo; Resnati, Giuseppe.

In: Journal of the American Chemical Society, Vol. 136, No. 24, 18.06.2014, p. 8524-8527.

Research output: Contribution to journal › Article › peer-review

Tirotta, I, Mastropietro, A, Cordiglieri, C, Gazzera, L, Baggi, F, Baselli, G, Grazia Bruzzone, M, Zucca, I, Cavallo, G, Terraneo, G, Baldelli Bombelli, F, Metrangolo, P & Resnati, G 2014, 'A superfluorinated molecular probe for highly sensitive in vivo ¹⁹F-MRI', Journal of the American Chemical Society, vol. 136, no. 24, pp. 8524-8527. https://doi.org/10.1021/ja503270n

Tirotta, Ilaria ; Mastropietro, Alfonso ; Cordiglieri, Chiara ; Gazzera, Lara ; Baggi, Fulvio ; Baselli, Giuseppe ; Grazia Bruzzone, Maria ; Zucca, Ileana ; Cavallo, Gabriella ; Terraneo, Giancarlo ; Baldelli Bombelli, Francesca ; Metrangolo, Pierangelo ; Resnati, Giuseppe. / A superfluorinated molecular probe for highly sensitive in vivo ¹⁹F-MRI. In: Journal of the American Chemical Society. 2014 ; Vol. 136, No. 24. pp. 8524-8527.

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abstract = "19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.",

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AU - Resnati, Giuseppe

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