A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

Ilaria Tirotta, Alfonso Mastropietro, Chiara Cordiglieri, Lara Gazzera, Fulvio Baggi, Giuseppe Baselli, Maria Grazia Bruzzone, Ileana Zucca, Gabriella Cavallo, Giancarlo Terraneo, Francesca Baldelli Bombelli, Pierangelo Metrangolo, Giuseppe Resnati

Research output: Contribution to journalArticlepeer-review

Abstract

19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.

Original languageEnglish
Pages (from-to)8524-8527
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number24
DOIs
Publication statusPublished - Jun 18 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry
  • Medicine(all)

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