A survey on hematology-oncology pediatric AIEOP centers: Prophylaxis, empirical therapy and nursing prevention procedures of infectious complications

Susanna Livadiotti, Giuseppe Maria Milano, Annalisa Serra, Laura Folgori, Alessandro Jenkner, Elio Castagnola, Simone Cesaro, Mario R. Rossi, Angelica Barone, Giulio Zanazzo, Francesca Nesi, Maria Licciardello, Raffaella De Santis, Ottavio Ziino, Monica Cellini, Fulvio Porta, Desiree Caselli, Giuseppe Pontrelli

Research output: Contribution to journalArticlepeer-review

Abstract

A nationwide questionnaire-based survey was designed to evaluate the management and prophylaxis of febrile neutrope-nia in pediatric patients admitted to hematology-oncology and hematopoietic stem cell transplant units. Of the 34 participating centers, 40 and 63%, respectively, continue to prescribe antibacterial and antimycotic prophylaxis in low-risk subjects and 78 and 94% in transplant patients. Approximately half of the centers prescribe a combination antibiotic regimen as first-line therapy in low-risk patients and up to 81% in high-risk patients. When initial empirical therapy fails after seven days, 63% of the centers add empirical antimycotic therapy in low-and 81% in high-risk patients. Overall management varies significantly across centers. Preventive nursing procedures are in accordance with international guidelines. This survey is the first to focus on prescribing practices in children with cancer and could help to implement practice guidelines.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalHaematologica
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

Keywords

  • Empirical therapy
  • Infectious diseases
  • Neutropenia fever
  • Pedi-atric
  • Prophylaxis

ASJC Scopus subject areas

  • Hematology

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