TY - JOUR
T1 - A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation
AU - D'Esposito, Maurizio
AU - Ciccodicola, Alfredo
AU - Gianfrancesco, Fernando
AU - Esposito, Teresa
AU - Flagiello, Luisa
AU - Mazzarella, Richard
AU - Schlessinger, David
AU - D'Urso, Michele
PY - 1996/6
Y1 - 1996/6
N2 - The X and Y chromosomes that maintain human dimorphism are thought to have descended from a single progenitor, with the Y chromosome becoming largely depleted of genes. A number of genes, however, retain copies on both X and Y chromosomes and escape the inactivation that affects most X-linked genes in somatic cells. Many of those genes are present in two pseudoautosomal regions (PARs) at the termini of the short (p)3 and long (q)4,5 arms of the sex chromosomes. For both PARs, pairing facilitates the exchange of information, ensuring the homogenisation of X and Y chromosomal material in these regions. We report here a strikingly different regulation of expression of a gene in Xq PAR. Unlike all Xp PAR genes studied so far, a synaptobrevin-like gene, tentatively named SYBL1, undergoes X inactivation. In addition, it is also inactive on the Y chromosome, thereby maintaining dosage compensation in an unprecedented way.
AB - The X and Y chromosomes that maintain human dimorphism are thought to have descended from a single progenitor, with the Y chromosome becoming largely depleted of genes. A number of genes, however, retain copies on both X and Y chromosomes and escape the inactivation that affects most X-linked genes in somatic cells. Many of those genes are present in two pseudoautosomal regions (PARs) at the termini of the short (p)3 and long (q)4,5 arms of the sex chromosomes. For both PARs, pairing facilitates the exchange of information, ensuring the homogenisation of X and Y chromosomal material in these regions. We report here a strikingly different regulation of expression of a gene in Xq PAR. Unlike all Xp PAR genes studied so far, a synaptobrevin-like gene, tentatively named SYBL1, undergoes X inactivation. In addition, it is also inactive on the Y chromosome, thereby maintaining dosage compensation in an unprecedented way.
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U2 - 10.1038/ng0696-227
DO - 10.1038/ng0696-227
M3 - Article
C2 - 8640232
AN - SCOPUS:0030028167
VL - 13
SP - 227
EP - 229
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -