A synthetic analog of prostaglandin E2 is able to induce in vivo theta antigen on spleen cells of adult thymectomized mice

Enrico Garaci, Cristina Rinaldi-Garaci, Vera Del Gobbo, Cartesio Favalli, M. Gabriella Santoro, Bernard M. Jaffe

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Abstract

The effect of prostaglandins on the in vivo induction of theta antigen in splenic spontaneous rosette-forming cells derived from adult thymectomized mice was studied. A long-acting synthetic analog of prostaglandin E2, di-M-PGE2, mimicked the effects of thymic hormone and was active when mice were treated with as little as 0.1 μg ip. In addition, indomethacin, a potent inhibitor of prostaglandin biosynthesis, was able to reverse the inductive effects of exogenous thymic hormone and inhibit the expression of theta antigen in normal mice, presumably by interfering with the effect of endogenous thymic factors. Finally, indomethacin also partially suppressed the stimulatory effects of exogenously administered di-M-PGE2, suggesting that this agent is effective, at least in part, because it stimulates endogenous prostaglandin biosynthesis. Possible mechanisms of action for the effects of prostaglandins are presented.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalCellular Immunology
Volume62
Issue number1
DOIs
Publication statusPublished - Jul 15 1981

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ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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