Abstract
We present a hypothesis on the mechanisms used by cells to transport cargo through the secretory system. We propose that at least three basic processes coordinately participate in membrane traffic: cisternal maturation- progression, controlled cargo diffusion along transient membrane continuities between different compartments, and a mostly retrograde vesicle-mediated transport. A 'synthetic' model based on the combination of these mechanisms can explain both the progression of supramolecular aggregates through the secretory pathway and the fast intra-Golgi transport of conventional cargoes. Analysis of the existing literature shows that the available data are consistent with the proposed model.
Original language | English |
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Pages (from-to) | 249-252 |
Number of pages | 4 |
Journal | FASEB Journal |
Volume | 12 |
Issue number | 2 |
Publication status | Published - 1998 |
Keywords
- Cistern maturation
- Golgi enzyme recycling
- Intra-Golgi transport
- Lateral diffusion
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology