A synthetic model of intra-Golgi traffic

Alexander Mironov, Alberto Luini, Alexander Mironov

Research output: Contribution to journalArticle

Abstract

We present a hypothesis on the mechanisms used by cells to transport cargo through the secretory system. We propose that at least three basic processes coordinately participate in membrane traffic: cisternal maturation- progression, controlled cargo diffusion along transient membrane continuities between different compartments, and a mostly retrograde vesicle-mediated transport. A 'synthetic' model based on the combination of these mechanisms can explain both the progression of supramolecular aggregates through the secretory pathway and the fast intra-Golgi transport of conventional cargoes. Analysis of the existing literature shows that the available data are consistent with the proposed model.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalFASEB Journal
Volume12
Issue number2
Publication statusPublished - 1998

Keywords

  • Cistern maturation
  • Golgi enzyme recycling
  • Intra-Golgi transport
  • Lateral diffusion

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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  • Cite this

    Mironov, A., Luini, A., & Mironov, A. (1998). A synthetic model of intra-Golgi traffic. FASEB Journal, 12(2), 249-252.