A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins

Daniel J. Antoine, Helena Erlandsson Harris, Ulf Andersson, Kevin J. Tracey, Marco E. Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.

Original languageEnglish
Pages (from-to)135-137
Number of pages3
JournalMolecular medicine (Cambridge, Mass.)
Volume20
Issue number1
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

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