A Systematic Review of Biocompatible Cardiopulmonary Bypass Circuits and Clinical Outcome

Marco Ranucci, Anna Balduini, Antonio Ditta, Alessandra Boncilli, Simonetta Brozzi

Research output: Contribution to journalArticlepeer-review

Abstract

This systematic review and meta-analysis explores the clinical efficacy of biocompatible surfaces for cardiopulmonary bypass in adults. Thirty-six randomized controlled trials were retrieved for a total of 4360 patients. Patients treated with biocompatible circuits had a lower rate of packed red cells transfusions and atrial fibrillation, and shorter durations of stay in the intensive care unit. When the analysis was limited to high-quality studies, only a reduction in atrial fibrillation rate and a shorter stay in the intensive care unit remained significantly associated with the use of biocompatible surfaces. Using biocompatible surfaces without other measures to contain blood activation results in a limited clinical benefit.

Original languageEnglish
Pages (from-to)1311-1319
Number of pages9
JournalAnnals of Thoracic Surgery
Volume87
Issue number4
DOIs
Publication statusPublished - Apr 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

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