TY - JOUR
T1 - A Systematic Review of Biocompatible Cardiopulmonary Bypass Circuits and Clinical Outcome
AU - Ranucci, Marco
AU - Balduini, Anna
AU - Ditta, Antonio
AU - Boncilli, Alessandra
AU - Brozzi, Simonetta
PY - 2009/4
Y1 - 2009/4
N2 - This systematic review and meta-analysis explores the clinical efficacy of biocompatible surfaces for cardiopulmonary bypass in adults. Thirty-six randomized controlled trials were retrieved for a total of 4360 patients. Patients treated with biocompatible circuits had a lower rate of packed red cells transfusions and atrial fibrillation, and shorter durations of stay in the intensive care unit. When the analysis was limited to high-quality studies, only a reduction in atrial fibrillation rate and a shorter stay in the intensive care unit remained significantly associated with the use of biocompatible surfaces. Using biocompatible surfaces without other measures to contain blood activation results in a limited clinical benefit.
AB - This systematic review and meta-analysis explores the clinical efficacy of biocompatible surfaces for cardiopulmonary bypass in adults. Thirty-six randomized controlled trials were retrieved for a total of 4360 patients. Patients treated with biocompatible circuits had a lower rate of packed red cells transfusions and atrial fibrillation, and shorter durations of stay in the intensive care unit. When the analysis was limited to high-quality studies, only a reduction in atrial fibrillation rate and a shorter stay in the intensive care unit remained significantly associated with the use of biocompatible surfaces. Using biocompatible surfaces without other measures to contain blood activation results in a limited clinical benefit.
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U2 - 10.1016/j.athoracsur.2008.09.076
DO - 10.1016/j.athoracsur.2008.09.076
M3 - Article
C2 - 19324190
AN - SCOPUS:62649146066
VL - 87
SP - 1311
EP - 1319
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 4
ER -