A systemic antiviral resistance-inducing protein isolated from Clerodendrum inerme Gaertn. is a polynucleotide: adenosine glycosidase (ribosome-inactivating protein)

Fabiola Olivieri, Vivek Prasad, Paola Valbonesi, Shalini Srivastava, Papiya Ghosal-Chowdhury, Luigi Barbieri, Andrea Bolognesi, Fiorenzo Stirpe

Research output: Contribution to journalArticlepeer-review

Abstract

Two systemic antiviral resistance-inducing proteins, CIP-29 and CIP-34, isolated from Clerodendrum inerme Gaertn. leaves, were tested for ribosome-inactivating properties. It was found that CIP-29 has the characteristics of a polynucleotide: adenosine glycosidase (ribosome-inactivating protein), in that it inhibits protein synthesis both in cell-free systems and, at higher concentrations, in cells, and releases adenine from ribosomes, RNA, poly(A) and DNA. As compared with other known RIPs, CIP-29 deadenylates DNA at a high rate, and induces systemic antiviral resistance in susceptible plants.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalFEBS Letters
Volume396
Issue number2-3
DOIs
Publication statusPublished - Nov 4 1996

Keywords

  • Antiviral protein
  • Polynucleotide:adenosine glycosidase
  • Ribosome-inactivating protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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