A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications

Francesca Conserva, Loreto Gesualdo, Massimo Papale

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetic nephropathy (DN), a microvascular complication occurring in approximately 20-40% of patients with type 2 diabetes mellitus (T2DM), is characterized by the progressive impairment of glomerular filtration and the development of Kimmelstiel-Wilson lesions leading to end-stage renal failure (ESRD). The causes and molecular mechanisms mediating the onset of T2DM chronic complications are yet sketchy and it is not clear why disease progression occurs only in some patients. We performed a systematic analysis of the most relevant studies investigating genetic susceptibility and specific transcriptomic, epigenetic, proteomic, and metabolomic patterns in order to summarize the most significant traits associated with the disease onset and progression. The picture that emerges is complex and fascinating as it includes the regulation/dysregulation of numerous biological processes, converging toward the activation of inflammatory processes, oxidative stress, remodeling of cellular function and morphology, and disturbance of metabolic pathways. The growing interest in the characterization of protein post-translational modifications and the importance of handling large datasets using a systems biology approach are also discussed.

Original languageEnglish
Pages (from-to)7934504
JournalJournal of Diabetes Research
Volume2016
DOIs
Publication statusPublished - 2016

Keywords

  • Animals
  • Diabetes Mellitus, Type 2
  • Diabetic Nephropathies
  • Disease Progression
  • Epigenesis, Genetic
  • Gene Expression Profiling
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Kidney
  • Metabolomics
  • Phenotype
  • Protein Processing, Post-Translational
  • Proteomics
  • RNA Processing, Post-Transcriptional
  • Risk Factors
  • Systems Biology
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Fingerprint Dive into the research topics of 'A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications'. Together they form a unique fingerprint.

Cite this