A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies

Antonella Viola, Susanne Linkert, Antonio Lanzavecchia

Research output: Contribution to journalArticlepeer-review

Abstract

It has been demonstrated that modified peptides which fail to induce detectable T cell responses can act as T cell receptor (TCR) antagonists when presented together with agonist by the same antigen-presenting cell (APC). We report that a TCR antagonist competitively inhibits TCR triggering induced by low-affinity ligands such as agonistic peptides or bacterial superantigens. However, the same antagonist cannot inhibit TCR triggering and T cell activation induced by high-affinity anti-CD3 antibodies that engage most TCR at once. These results indicate that TCR antagonists inhibit T cell responses by interfering with the ongoing process of serial triggering, rather than by delivering an inhibitory signal to T cells.

Original languageEnglish
Pages (from-to)3080-3083
Number of pages4
JournalEuropean Journal of Immunology
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 1997

Keywords

  • Low- and high-affinity ligands
  • T cell receptor antagonism
  • T cell receptor downregulation
  • T cell receptor serial triggering

ASJC Scopus subject areas

  • Immunology

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