A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma

G. Sozzi, I. Bongarzone, M. Miozzo, M. G. Borrello, M. G. Butti, S. Pilotti, G. Della Porta, M. A. Pierotti

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Abstract

Activation of the RET protooncogene tyrosine kinase (tk) by fusion with other genes is a frequent finding in papillary thyroid carcinoma. The tk domain of proto-RET can be fused either with the D10S170 gene generating the RET/PTC1 transforming sequence or with sequences belonging to the gene encoding the regulatory subunit RIA of c-AMP-dependent protein kinase A, thus forming the RET/PTC2 oncogene. We have previously shown that an inversion of chromosome 10, inv(10)(q11.2q21), is responsible for the generation of the RET/PTC1. Here we report that a chromosomal translocation, t(10;17)(q11.2;q23), juxtaposes the tk domain of the RET protooncogene, which resides on chromosome 10, to a 5' portion of the RIA gene on chromosome 17, leading to the formation of the chimeric transforming gene RET/PTC2. The finding of the transforming protein in primary tumor cell extracts supports the conclusion that RET/PTC2 activation plays a role in papillary thyroid tumorigenesis.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalGenes Chromosomes and Cancer
Volume9
Issue number4
Publication statusPublished - 1994

Fingerprint

Protein-Tyrosine Kinases
Chromosomes, Human, Pair 10
Oncogenes
Genes
Genetic Translocation
Chromosomes, Human, Pair 17
Adenosine Monophosphate
Regulator Genes
Cyclic AMP-Dependent Protein Kinases
Cell Extracts
Thyroid Gland
Carcinogenesis
Papillary Thyroid cancer
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma. / Sozzi, G.; Bongarzone, I.; Miozzo, M.; Borrello, M. G.; Butti, M. G.; Pilotti, S.; Della Porta, G.; Pierotti, M. A.

In: Genes Chromosomes and Cancer, Vol. 9, No. 4, 1994, p. 244-250.

Research output: Contribution to journalArticle

Sozzi, G, Bongarzone, I, Miozzo, M, Borrello, MG, Butti, MG, Pilotti, S, Della Porta, G & Pierotti, MA 1994, 'A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma', Genes Chromosomes and Cancer, vol. 9, no. 4, pp. 244-250.
Sozzi, G. ; Bongarzone, I. ; Miozzo, M. ; Borrello, M. G. ; Butti, M. G. ; Pilotti, S. ; Della Porta, G. ; Pierotti, M. A. / A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma. In: Genes Chromosomes and Cancer. 1994 ; Vol. 9, No. 4. pp. 244-250.
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AU - Borrello, M. G.

AU - Butti, M. G.

AU - Pilotti, S.

AU - Della Porta, G.

AU - Pierotti, M. A.

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AB - Activation of the RET protooncogene tyrosine kinase (tk) by fusion with other genes is a frequent finding in papillary thyroid carcinoma. The tk domain of proto-RET can be fused either with the D10S170 gene generating the RET/PTC1 transforming sequence or with sequences belonging to the gene encoding the regulatory subunit RIA of c-AMP-dependent protein kinase A, thus forming the RET/PTC2 oncogene. We have previously shown that an inversion of chromosome 10, inv(10)(q11.2q21), is responsible for the generation of the RET/PTC1. Here we report that a chromosomal translocation, t(10;17)(q11.2;q23), juxtaposes the tk domain of the RET protooncogene, which resides on chromosome 10, to a 5' portion of the RIA gene on chromosome 17, leading to the formation of the chimeric transforming gene RET/PTC2. The finding of the transforming protein in primary tumor cell extracts supports the conclusion that RET/PTC2 activation plays a role in papillary thyroid tumorigenesis.

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