A-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect

Elisabetta Làdavas, Sara Giulietti, Alessio Avenanti, Caterina Bertini, Eleonora Lorenzini, Cristina Quinquinio, Andrea Serino

Research output: Contribution to journalArticlepeer-review


Background and objective: The aim of the study is to compare the effects of multiple sessions of cathodal (c-tDCS) or anodal tDCS (a-tDCS) in modulating the beneficial effects of prism adaptation (PA) treatment in neglect patients. Methods: 30 neglect patients were submitted to 10 daily sessions of PA treatment. Patients were pseudo-randomly divided into 3 groups. In the c-tDCS-group, each PA session was coupled with 20 minutes of cathodal stimulation of the left, intact PPC; in the a-tDCS-group, anodal stimulation was applied to PPC of the damaged hemisphere; in the Sham group, sham stimulation was applied. Neglect was evaluated before and after treatment with the Behavioral Inattention Test. Results: Combined tDCS-PA treatment induced stronger neglect improvement in the a-tDCS group as compared to the Sham group. No improvement was found in the c-tDCSgroup, with respect to that normally induced by PA and found in the Sham group. Conclusions: c-tDCS abolished neglect amelioration after PA, possibly because stimulation affected the sensorimotor network controlling prism adaptation. Instead, a-tDCS PPC boosted neglect amelioration after PAprobably thanks to increased excitability of residual tissue in the lesioned hemisphere, which in turn might reduce dysfunctional over-excitability of the intact hemisphere.

Original languageEnglish
Pages (from-to)647-662
Number of pages16
JournalRestorative Neurology and Neuroscience
Issue number5
Publication statusPublished - Oct 5 2015


  • Neglect
  • Prism Adaptation
  • tDCS

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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