A tentative interpretation of electromyographic regional differences in bulbar- and limb-onset ALS

A. Cappellari, A. Brioschi, S. Barbieri, M. Braga, G. Scarlato, Vincenzo Silani

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Abstract

Electromyography (EMG) could be useful in defining regional motor neuron vulnerability in ALS. We performed EMG in 36 sporadic ALS patients (9 with bulbar-onset and 27 with limb-onset symptoms). Active denervation was more frequent in limb than in corresponding paraspinal muscles, in the thoracic paraspinal, and in the bulbo-cervical muscles in patients with bulbar-onset symptoms. These results are consistent with a regional motor neuron vulnerability along with a nerve length-dependent liability.

Original languageEnglish
Pages (from-to)644-646
Number of pages3
JournalNeurology
Volume52
Issue number3
Publication statusPublished - Feb 1999

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ASJC Scopus subject areas

  • Neuroscience(all)

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