A TH1→TH2 switch is a critical step in the etiology of HIV infection

Mario Clerici, Gene M. Shearer

Research output: Contribution to journalArticle

1180 Citations (Scopus)

Abstract

This viewpoint proposes that an imbalance in the TH1-type and TH2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a TH > TH2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2 and IFN-γ production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong TH1-type responses to HIV antigens.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalImmunology Today
Volume14
Issue number3
DOIs
Publication statusPublished - 1993

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HIV Infections
Interleukin-2
Acquired Immunodeficiency Syndrome
HIV Antigens
Interleukin-4
Interleukin-10
HIV

ASJC Scopus subject areas

  • Immunology

Cite this

A TH1→TH2 switch is a critical step in the etiology of HIV infection. / Clerici, Mario; Shearer, Gene M.

In: Immunology Today, Vol. 14, No. 3, 1993, p. 107-111.

Research output: Contribution to journalArticle

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