A TH1→TH2 switch is a critical step in the etiology of HIV infection

Mario Clerici, Gene M. Shearer

Research output: Contribution to journalArticle

Abstract

This viewpoint proposes that an imbalance in the TH1-type and TH2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a TH > TH2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2 and IFN-γ production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong TH1-type responses to HIV antigens.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalTrends in Immunology
Volume14
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'A TH1→TH2 switch is a critical step in the etiology of HIV infection'. Together they form a unique fingerprint.

  • Cite this