A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography

Francesco Scopinaro, Orazio Schillaci, Wolf Ussof, Ketil Nordling, Renato Capoferro, Giuseppe De Vincentis, Roberta Danieli, Maria Ierardi, Valentina Picardi, Rosanna Tavolaro, Antonio Centi Colella

Research output: Contribution to journalArticlepeer-review


In order to assess specificity and sensitivity of the prone scintimammography (PSM) in a large series with 99m-Tc MIBI, we performed a three-center study; 420 patients were studied: after mammography all the patients were submitted to PSM and biopsy and/or operation. PSM was considered positive if hot spot within the breast was observed. In palpable masses sensitivity was 0.98 and specificity 0.89, non palpable masses showed a sensitivity of 0.62 and a specificity of 0.91. When the cancers were stratified for T category the sensitivity was 0.28 in T(1s), 0.26 in the group T(1a) carcinomas, 0.56 in T(1b), 0.95 in T(1c), and 0.97 T2 tumors. Physical factors such as attenuation, Compton scattering from chest, as well as biological factors have a role in breast tumor imaging. In the tumors smaller than 1cm biological factors are probably involved too.

Original languageEnglish
Pages (from-to)1631-1634
Number of pages4
JournalAnticancer Research
Issue number3 B
Publication statusPublished - 1997


  • Breast cancer
  • Diagnostic accuracy
  • Sestamibi
  • Tumor size

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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