A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography

Francesco Scopinaro, Orazio Schillaci, Wolf Ussof, Ketil Nordling, Renato Capoferro, Giuseppe De Vincentis, Roberta Danieli, Maria Ierardi, Valentina Picardi, Rosanna Tavolaro, Antonio Centi Colella

Research output: Contribution to journalArticle

Abstract

In order to assess specificity and sensitivity of the prone scintimammography (PSM) in a large series with 99m-Tc MIBI, we performed a three-center study; 420 patients were studied: after mammography all the patients were submitted to PSM and biopsy and/or operation. PSM was considered positive if hot spot within the breast was observed. In palpable masses sensitivity was 0.98 and specificity 0.89, non palpable masses showed a sensitivity of 0.62 and a specificity of 0.91. When the cancers were stratified for T category the sensitivity was 0.28 in T(1s), 0.26 in the group T(1a) carcinomas, 0.56 in T(1b), 0.95 in T(1c), and 0.97 T2 tumors. Physical factors such as attenuation, Compton scattering from chest, as well as biological factors have a role in breast tumor imaging. In the tumors smaller than 1cm biological factors are probably involved too.

Original languageEnglish
Pages (from-to)1631-1634
Number of pages4
JournalAnticancer Research
Volume17
Issue number3 B
Publication statusPublished - 1997

Fingerprint

Biological Factors
Technetium Tc 99m Sestamibi
Neoplasms
Mammography
Breast
Thorax
Breast Neoplasms
Carcinoma
Biopsy
Sensitivity and Specificity

Keywords

  • Breast cancer
  • Diagnostic accuracy
  • Sestamibi
  • Tumor size

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Scopinaro, F., Schillaci, O., Ussof, W., Nordling, K., Capoferro, R., De Vincentis, G., ... Colella, A. C. (1997). A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography. Anticancer Research, 17(3 B), 1631-1634.

A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography. / Scopinaro, Francesco; Schillaci, Orazio; Ussof, Wolf; Nordling, Ketil; Capoferro, Renato; De Vincentis, Giuseppe; Danieli, Roberta; Ierardi, Maria; Picardi, Valentina; Tavolaro, Rosanna; Colella, Antonio Centi.

In: Anticancer Research, Vol. 17, No. 3 B, 1997, p. 1631-1634.

Research output: Contribution to journalArticle

Scopinaro, F, Schillaci, O, Ussof, W, Nordling, K, Capoferro, R, De Vincentis, G, Danieli, R, Ierardi, M, Picardi, V, Tavolaro, R & Colella, AC 1997, 'A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography', Anticancer Research, vol. 17, no. 3 B, pp. 1631-1634.
Scopinaro F, Schillaci O, Ussof W, Nordling K, Capoferro R, De Vincentis G et al. A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography. Anticancer Research. 1997;17(3 B):1631-1634.
Scopinaro, Francesco ; Schillaci, Orazio ; Ussof, Wolf ; Nordling, Ketil ; Capoferro, Renato ; De Vincentis, Giuseppe ; Danieli, Roberta ; Ierardi, Maria ; Picardi, Valentina ; Tavolaro, Rosanna ; Colella, Antonio Centi. / A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography. In: Anticancer Research. 1997 ; Vol. 17, No. 3 B. pp. 1631-1634.
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