A-to-I RNA editing and cancer: From pathology to basic science

Angela Gallo, Silvia Galardi

Research output: Contribution to journalArticle

Abstract

In eukaryotes mRNA transcripts are extensively processed by different post-transcriptional events such as alternative splicing and RNA editing in order to generate many different mRNAs from the same gene, increasing the transcriptome and then the proteome. The most frequent RNA editing mechanism in mammals involves the conversion of specific adenosines into inosines by the ADAR family of enzymes. This editing event can change both the sequence and the secondary structure of RNA molecules, with important consequences on both the final proteins and regulatory RNAs. Alteration in RNA editing has been connected to numerous human pathologies and recent studies have demonstrated its importance in tumor progression.

Original languageEnglish
JournalRNA Biology
Volume5
Issue number3
Publication statusPublished - Jul 2008

Keywords

  • ADARs
  • Astrocytomas
  • Cancer
  • GBM
  • Inosine
  • MicroRNA
  • Post-transcriptional regulation
  • RNA binding protein
  • RNA editing

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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