A to O bone marrow transplantation was performed in a 25 yr old male affected with severe aplastic anemia, the donor being an HLA compatible brother. Three plasma exchanges had to be performed with an Aminco separator to remove the original and recurring anti A isohemagglutinins. The dynamics of O to A blood group conversion were followed by means of differential agglutination. An early wave of marked dyserythropoiesis was observed in the engrafted marrow. Mild to moderate GvHD was treated successfully with MTX, bolus high dosage 6 methylprednisolone and, at relapse, with intravenous ALG.
|Number of pages||8|
|Journal||British Journal of Haematology|
|Publication status||Published - 1977|
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