A tumor suppressor locus in familial and sporadic chordoma maps to 1p36

Monica Miozzo, Leda Dalprà, Paola Riva, Marinella Volontè, Fabio Macciardi, Sergio Pericotti, M. Grazia Tibiletti, Michele Cerati, Klaus Rohde, Lidia Larizza, A. Maria Fuhrman Conti

Research output: Contribution to journalArticlepeer-review

Abstract

Previous cytogenetic/FISH data have demonstrated 1p36 deletions in a relapsing familial clivus chordoma developed by a patient who has 2 daughters, respectively affected with childhood astrocytoma and clivus chordoma. Using an approach that combined the LOH (loss of heterozygosity) study of the father chordoma and the daughter astrocytoma and a segregation analysis from parents to sibs using 17 CA-repeats spanning 1p36.32-1p36.11, we mapped the cancer susceptibility locus in this family to the 1p36 region. The LOH and haplotype information was elaborated using a pairwise linkage analysis that gave a maximum lod score of 1.2. Additional LOH data relating to 6 sporadic chordomas allowed us to define an SRO (the smallest region of overlapping loss) of about 25 cM from D1S2845 (1p36.31) to D1S2728 (1p36.13). Our overall findings converge on mapping to 1p36 a tumor-suppressor gene involved in familial and sporadic chordoma. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalInternational Journal of Cancer
Volume87
Issue number1
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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