Abstract
Previous cytogenetic/FISH data have demonstrated 1p36 deletions in a relapsing familial clivus chordoma developed by a patient who has 2 daughters, respectively affected with childhood astrocytoma and clivus chordoma. Using an approach that combined the LOH (loss of heterozygosity) study of the father chordoma and the daughter astrocytoma and a segregation analysis from parents to sibs using 17 CA-repeats spanning 1p36.32-1p36.11, we mapped the cancer susceptibility locus in this family to the 1p36 region. The LOH and haplotype information was elaborated using a pairwise linkage analysis that gave a maximum lod score of 1.2. Additional LOH data relating to 6 sporadic chordomas allowed us to define an SRO (the smallest region of overlapping loss) of about 25 cM from D1S2845 (1p36.31) to D1S2728 (1p36.13). Our overall findings converge on mapping to 1p36 a tumor-suppressor gene involved in familial and sporadic chordoma. (C) 2000 Wiley-Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 68-72 |
| Number of pages | 5 |
| Journal | International Journal of Cancer |
| Volume | 87 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
A tumor suppressor locus in familial and sporadic chordoma maps to 1p36. / Miozzo, Monica; Dalprà, Leda; Riva, Paola; Volontè, Marinella; Macciardi, Fabio; Pericotti, Sergio; Tibiletti, M. Grazia; Cerati, Michele; Rohde, Klaus; Larizza, Lidia; Fuhrman Conti, A. Maria.
In: International Journal of Cancer, Vol. 87, No. 1, 2000, p. 68-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A tumor suppressor locus in familial and sporadic chordoma maps to 1p36
AU - Miozzo, Monica
AU - Dalprà, Leda
AU - Riva, Paola
AU - Volontè, Marinella
AU - Macciardi, Fabio
AU - Pericotti, Sergio
AU - Tibiletti, M. Grazia
AU - Cerati, Michele
AU - Rohde, Klaus
AU - Larizza, Lidia
AU - Fuhrman Conti, A. Maria
PY - 2000
Y1 - 2000
N2 - Previous cytogenetic/FISH data have demonstrated 1p36 deletions in a relapsing familial clivus chordoma developed by a patient who has 2 daughters, respectively affected with childhood astrocytoma and clivus chordoma. Using an approach that combined the LOH (loss of heterozygosity) study of the father chordoma and the daughter astrocytoma and a segregation analysis from parents to sibs using 17 CA-repeats spanning 1p36.32-1p36.11, we mapped the cancer susceptibility locus in this family to the 1p36 region. The LOH and haplotype information was elaborated using a pairwise linkage analysis that gave a maximum lod score of 1.2. Additional LOH data relating to 6 sporadic chordomas allowed us to define an SRO (the smallest region of overlapping loss) of about 25 cM from D1S2845 (1p36.31) to D1S2728 (1p36.13). Our overall findings converge on mapping to 1p36 a tumor-suppressor gene involved in familial and sporadic chordoma. (C) 2000 Wiley-Liss, Inc.
AB - Previous cytogenetic/FISH data have demonstrated 1p36 deletions in a relapsing familial clivus chordoma developed by a patient who has 2 daughters, respectively affected with childhood astrocytoma and clivus chordoma. Using an approach that combined the LOH (loss of heterozygosity) study of the father chordoma and the daughter astrocytoma and a segregation analysis from parents to sibs using 17 CA-repeats spanning 1p36.32-1p36.11, we mapped the cancer susceptibility locus in this family to the 1p36 region. The LOH and haplotype information was elaborated using a pairwise linkage analysis that gave a maximum lod score of 1.2. Additional LOH data relating to 6 sporadic chordomas allowed us to define an SRO (the smallest region of overlapping loss) of about 25 cM from D1S2845 (1p36.31) to D1S2728 (1p36.13). Our overall findings converge on mapping to 1p36 a tumor-suppressor gene involved in familial and sporadic chordoma. (C) 2000 Wiley-Liss, Inc.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034084439&partnerID=8YFLogxK
U2 - 10.1002/1097-0215(20000701)87:1<68::AID-IJC10>3.0.CO;2-V
DO - 10.1002/1097-0215(20000701)87:1<68::AID-IJC10>3.0.CO;2-V
M3 - Article
C2 - 10861454
AN - SCOPUS:0034084439
VL - 87
SP - 68
EP - 72
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 1
ER -