A tumour score with multidetector spiral CT for venous infiltration in pancreatic cancer: Influence on borderline resectable

Tiziana Marinelli, Antonella Filippone, Francesca Tavano, Andrea Fontana, Fabio Pellegrini, Jörg Köninger, Götz M. Richter, Lorenzo Bonomo, Markus W. Büchler, Pierluigi Di Sebastiano, Francesco F. Di Mola

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: A tumour score for venous invasion in patients with pancreatic adenocarcinoma was evaluated by means of computed tomography (CT), in order to improve the assessment of medical treatment and clinical outcome with special attention to borderline resectable disease. Materials and methods: Fifty-six consecutive patients who underwent curative surgical resection for pancreatic cancer were analysed. On the basis of CT criteria, tumour involvement of the portal vein (PV) and superior mesenteric vein (SMV) was graded according to an adapted 4-point scale: score 1, definite absence of invasion; score 2, probable absence of invasion; score 3, probable presence of invasion; score 4, definite presence of invasion. Correlations between the venous infiltration scores and the patients' clinical features were also evaluated. Results: After radiological evaluation of PV and SMV grades of infiltration, 21/56 (37 %) and 37/56 (66 %) patients, respectively, were found to have borderline resectable disease. The 4-point scale achieved a sensitivity of 80 %, a specificity of 96 % and an accuracy of 93 % in the evaluation of the PV, and a sensitivity of 100 %, a specificity of 94 % and an accuracy of 95 % in the evaluation of the SMV. Analysis of the distribution of clinical characteristics by PV and SMV infiltration showed that both scores correlated with the presence of distal metastasis (p = 0.016 and p = 0.028, respectively), and resection margins status (p = 0.015 and p = 0.006, respectively). Conclusions: This adapted tumour score is reliable for assessing venous invasion and might improve preoperative staging in patients with borderline resectable pancreatic cancer.

Original languageEnglish
Pages (from-to)334-342
Number of pages9
JournalRadiologia Medica
Volume119
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Borderline resectable lesion
  • CT scan
  • Pancreatic cancer
  • Prognostic factors
  • Vein infiltration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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