A two-locus model for familial Alzheimer's disease?

F. Macciardi, M. C. Cavallini

Research output: Contribution to journalArticlepeer-review


The present findings for familial Alzheimer's disease suggest a possible linkage to gene(s) on chromosome 21 for the early onset form and to chromosome 19 for the late onset. Since these results are not unequivocal, possible alternative hypotheses include the effect of genetic heterogeneity or of an oligogenic model of segregation for FAD.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalGenetic Epidemiology
Issue number6
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology


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