A two-step selection of breast cancer patients candidates for exclusive IORT with electrons: A mono-institutional experience

Marina Guenzi, A. Fozza, G. Timon, L. Belgioia, G. Vidano, F. Cavagnetto, S. Agostinelli, M. Gusinu, F. Carli, F. Cafiero, D. Friedman, G. Canavese, R. Corvò

Research output: Contribution to journalArticle

Abstract

Aim: To assess the impact of a two-step multiparameter selection on the actual enrollment of women with breast cancer into a prospective intraoperative radiotherapy (IORT) trial. Patients and Methods: From September 2009, a prospective clinical trial was started in order to deliver adjuvant exclusive single -fraction IORT to patients with early breast cancer. To select patients meeting suitable eligibility criteria for the clinical trial, a two-step decision process was developed: at pre-surgical examination (first step) and during surgery (second step). Results: A series of 464 patients with breast cancer was analysed: at the first step, out of 464 patients, 333 (71%) were considered eligible for the IORT protocol; at the second step, out of 333 patients, 199 (60%) met the eligibility criteria and received the IORT fraction according to the criteria of the controlled trial. Conclusion: In our experience, the ultimate rate of patients who enrolled in the IORT clinical trial after the two-step decision process was 43%.

Original languageEnglish
Pages (from-to)1533-1536
Number of pages4
JournalAnticancer Research
Volume32
Issue number4
Publication statusPublished - Apr 2012

Keywords

  • Breast cancer
  • Decision process
  • Intraoperative radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'A two-step selection of breast cancer patients candidates for exclusive IORT with electrons: A mono-institutional experience'. Together they form a unique fingerprint.

  • Cite this

    Guenzi, M., Fozza, A., Timon, G., Belgioia, L., Vidano, G., Cavagnetto, F., Agostinelli, S., Gusinu, M., Carli, F., Cafiero, F., Friedman, D., Canavese, G., & Corvò, R. (2012). A two-step selection of breast cancer patients candidates for exclusive IORT with electrons: A mono-institutional experience. Anticancer Research, 32(4), 1533-1536.