A two-year survey of mucocutaneous lymph node syndrome in Northeastern Italy. Epidemiological and clinical findings

G. Tamburlini, R. Strinati, S. Cadorini, A. Calligaris, A. Coprivez, M. Cozzi, F. Da Giau, G. Guidobaldi, G. Lorusso, G. Messi

Research output: Contribution to journalArticlepeer-review

Abstract

A two-year retrospective survey of cases of mucocutaneous lymph node syndrome (MLNS, Kawasaki disease) was conducted by a collaborative research group in Northeastern Italy (Friuli Venezia-Giulia) by reviewing the records of all patients admitted in the paediatric wards of this area from January 1, 1981 to December 31, 1982. 19 cases of MLNS were identified representing an overall incidence in the two-year period of 14.7 cases per 100,000 children younger than 5 years of age. Seasonal clustering of cases was observed, 17 out of 19 cases occurring either in spring or automn (P = 0.0004, binomial distribution) and 11 out of 19 cases occurring in spring alone (P = 0.0023). No evidence for direct contact between cases or common source exposure emerged, and no risk factors were identified. The clinical spectrum of the disease was similar to that described elsewhere, carditis, uveitis, arthritis and urethritis being the most frequent complications. One infant died, and in this case coronary artery aneurysms were demonstrated by two-dimensional echocardiography. In the remaining cases recovery was complete without sequelae. This study suggests that MLNS is more frequent than expected and that the real incidence of the disease is probably underestimated. The evidence of seasonal clustering of cases strongly suggests the presence of a yet unidentified exogenous factor playing a role in the etiology of the disease.

Original languageEnglish
Pages (from-to)319-329
Number of pages11
JournalHelvetica Paediatrica Acta
Volume39
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'A two-year survey of mucocutaneous lymph node syndrome in Northeastern Italy. Epidemiological and clinical findings'. Together they form a unique fingerprint.

Cite this