A-type lamins and signaling: The PI 3-kinase/Akt pathway moves forward

Sandra Marmiroli, Jessika Bertacchini, Francesca Beretti, Vittoria Cenni, Marianna Guida, Anto De Pol, Nadir M. Maraldi, Giovanna Lattanzi

Research output: Contribution to journalArticle

Abstract

Lamin A/C is a nuclear lamina constituent mutated in a number of human inherited disorders collectively referred to as laminopathies. The occurrence and significance of lamin A/C interplay with signaling molecules is an old question, suggested by pioneer studies performed in vitro. However, this relevant question has remained substantially unanswered, until data obtained in cellular and organismal models of laminopathies have indicated two main aspects of lamin A function. The first aspect is that lamins establish functional interactions with different protein platforms, the second aspect is that lamin A/C activity and altered function may elicit different effects in different cells and tissue types and even in different districts of the same tissue. Both these observations strongly suggest that signaling mechanisms targeting lamin A/C or its binding partners may regulate such a plastic behavior. A number of very recent data show involvement of kinases, as Akt and Erk, or phosphatases, as PP1 and PP2, in lamin A-linked cellular mechanisms. Moreover, altered activation of signaling in laminopathies and rescue of the pathological phenotype in animal models by inhibitors of signaling pathways, strongly suggest that signaling effectors related to lamin A/C may be implicated in the pathogenesis of laminopathies and may represent targets of therapeutic intervention. In face of such an open perspective of basic and applied research, we review current evidence of lamin A/C interplay with signaling molecules, with particular emphasis on the lamin A-Akt interaction and on the biological significance of their relationship.

Original languageEnglish
Pages (from-to)553-564
Number of pages12
JournalJournal of Cellular Physiology
Volume220
Issue number3
DOIs
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

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    Marmiroli, S., Bertacchini, J., Beretti, F., Cenni, V., Guida, M., De Pol, A., Maraldi, N. M., & Lattanzi, G. (2009). A-type lamins and signaling: The PI 3-kinase/Akt pathway moves forward. Journal of Cellular Physiology, 220(3), 553-564. https://doi.org/10.1002/jcp.21807